2. Gene
  3. Agxt - alanine-glyoxylate aminotransferase Gene

Agxt - alanine-glyoxylate aminotransferase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as AGT; SPT; Agt1; Agxt1

Gene ID: 11611 | Gene type: protein coding

About Agxt

Summary

Enables alanine-glyoxylate transaminase activity. Acts upstream of or within Notch signaling pathway; glyoxylate metabolic process; and oxalic acid secretion. Predicted to be located in mitochondrial matrix and peroxisomal matrix. Predicted to be active in peroxisome. Is expressed in liver. Used to study primary hyperoxaluria type 1. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate and serine--pyruvate aminotransferase). [provided by Alliance of Genome Resources, Apr 2022]

Agxt Products(2)

mRNA Protein Name
NM_001276710.1 NP_001263639.1 serine--pyruvate aminotransferase, peroxisomal isoform 2
NM_016702.3 NP_057911.2 alanine--glyoxylate aminotransferase isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables alanine-glyoxylate transaminase activity IMP
IMP: Inferred from mutant phenotype
17110443 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Notch signaling pathway IDA
IDA: Inferred from direct assay
25446530 MGI
acts upstream of or within glyoxylate metabolic process IMP
IMP: Inferred from mutant phenotype
17110443 MGI
acts upstream of or within oxalic acid secretion IMP
IMP: Inferred from mutant phenotype
17110443 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alanine--glyoxylate aminotransferase

serine--pyruvate aminotransferase, peroxisomal

alanine-glyoxylate aminotransferase 1

serine--pyruvate aminotransferase, mitochondrial

serine-pyruvate aminotransferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-W023323 (S)-β-Aminoisobutyric acid hydrochloride 99.90% Unkown
HY-159910 LH1513 / Unkown
HY-RS00473 AGXT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00474 AGXT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Agxt NCBI NCBI:189