Ptprn - protein tyrosine phosphatase, receptor type, N Gene

Also Known as Ia-2; BEM-3; PTPLP; ICA105; ICA512; R-PTP-N

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 116660

Summary

Enables GTPase binding activity. Involved in several processes, including positive regulation of type B pancreatic cell proliferation; response to cAMP; and response to estrogen. Located in several cellular components, including axon terminus; neuronal cell body; and secretory granule. Colocalizes with Golgi apparatus; endosome; and plasma membrane. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine Phosphatase receptor type N). [provided by Alliance of Genome Resources, Apr 2022]

Ptprn Products (1)

mRNA Protein Name
NM_053881.2 NP_446333.2 receptor-type tyrosine-protein phosphatase-like N precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
16413169 RGD
Biological Process GO Annotation Evidence References Source
involved in positive regulation of type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
18178618 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
12351437 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
9607778 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
12351437 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
12351437 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
8641276 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
8641276 RGD
located in endosome IDA
IDA: Inferred from direct assay
8641276 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8641276 RGD
is active in neuronal dense core vesicle membrane IDA
IDA: Inferred from direct assay
8641276 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
8641276 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
8641276 RGD
located in synapse IDA
IDA: Inferred from direct assay
8641276 RGD
NOT located in synaptic vesicle IDA
IDA: Inferred from direct assay
8641276 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase-like N

  • 105 kDa islet cell antigen

  • brain-enriched membrane-associated protein tyrosine phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11445 PTPRN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11444 PTPRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20475 Ptprn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26983 Ptprn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ptprn NCBI NCBI:5798