PTPRN - protein tyrosine phosphatase receptor type N Gene

Also Known as IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5798

About PTPRN

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,289,623-219,309,401 (from NCBI)

This gene has 19 transcripts (splice variants), 258 orthologues and 35 paralogues. Biased expression in brain (RPKM 53.0), adrenal (RPKM 12.2) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

PTPRN Products (3)

mRNA Protein Name
NM_001199763.2 NP_001186692.1 receptor-type tyrosine-protein phosphatase-like N isoform 2 precursor
NM_001199764.2 NP_001186693.1 receptor-type tyrosine-protein phosphatase-like N isoform 3
NM_002846.4 NP_002837.1 receptor-type tyrosine-protein phosphatase-like N isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11086001 GOA
enables spectrin binding IPI
IPI: Inferred from physical interaction
11086001 GOA
enables transcription factor binding IDA
IDA: Inferred from direct assay
16622421 GOA
enables ubiquitin-like protein ligase binding IDA
IDA: Inferred from direct assay
15596545 GOA
Biological Process GO Annotation Evidence References Source
involved in dense core granule maturation IGI
IGI: Inferred from genetic interaction
24843546 GOA
involved in insulin secretion IGI
IGI: Inferred from genetic interaction
24843546 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15596545 GOA
involved in positive regulation of type B pancreatic cell proliferation IDA
IDA: Inferred from direct assay
18178618 GOA
involved in response to reactive oxygen species IDA
IDA: Inferred from direct assay
18048354 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15596545 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPRN Protein Structure

RESP18

RESP18: RESP18 domain (60 - 155)

Receptor_IA-2

Receptor_IA-2: Protein-tyrosine phosphatase receptor IA-2 (469 - 558)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (734 - 968)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 979 a.a.
Protein Preferred Names Protein Names

receptor-type tyrosine-protein phosphatase-like N

  • ICA 512

PTPRN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PTPRN Q16849 SPTBN4 Homo sapiens Q9H254
Anti Bait CoIP
11086001
Intra
PTPRN Q16849 SPTBN4 Homo sapiens Q9H254
Y2H
11086001
Intra
PTPRN Q16849 MADD Homo sapiens Q8WXG6
Anti Tag CoIP
16273344
Intra
PTPRN Q16849 MADD Homo sapiens Q8WXG6
Y2H
16273344
Intra
PTPRN Q16849 PPIA Homo sapiens P62937
Anti Tag CoIP
16273344
Intra
PTPRN Q16849 PTPRS Homo sapiens Q13332
Y2H
16273344
Intra
PTPRN Q16849 PTPRT Homo sapiens O14522
Y2H
16273344
Intra
PTPRN Q16849 SNX19 Homo sapiens Q92543
Anti Tag CoIP
16273344
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPRN Proteins

Cat. No. Product Name Accession Purity
HY-P70847 IA2 Protein, Human (293a.a, His, solution) Q16849-1 (M687-Q979) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70848 IA2 Protein, Human (His) Q16849-2 (R576-Q950) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70847A IA2 Protein, Human (293a.a, N-His) Q16849-1 (M687-Q979) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Insulinoma

  • Islet Cell Adenoma

  • Insulin-Producing Tumor Of Islet Cells

  • Adenoma Islet Cell

  • Islet Cell Tumor

  • Experimental Organism Islet Cell Adenoma Neoplasm
Type 1 Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetes Mellitus Type 1

  • IDDM

  • Type 1 Diabetes

  • Insulin-Dependent Diabetes Mellitus

  • T1D

  • Juvenile-Onset Diabetes

  • Jod

  • Diabetes Mellitus, Type 1

  • Diabetes Mellitus, Insulin-Dependent-1

  • Type I Diabetes Mellitus

  • Autoimmune Diabetes

  • Juvenile Diabetes

  • Juvenile-Onset Diabetes Mellitus

  • Diabetes, Insulin Dependent

  • Insulin-Dependent Diabetes Mellitus-1

  • Diabetes Mellitus Insulin-Dependent

  • Diabetes Autoimmune

  • Diabetes Mellitus, Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 1, Susceptibility To

  • Diabetes Type 1

  • Type I Diabetes

  • Diabetes, Autoimmune

  • T1dm - [Type 1 Diabetes Mellitus]

  • Iddm - [Insulin Dependent Diabetes Mellitus]

  • Type 1 Iddm

  • Juvenile Diabetes Mellitus Without Compications

  • Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

  • Juvenile-Onset Diabetes Mellitus Without Compications

  • Ketosis-Prone Diabetes Mellitus Without Compications

  • Juvenile-Onset-Type Diabetes Mellitus Without Compications
Diabetes Mellitus

  • Diabetes
Gestational Diabetes

  • Gestational Diabetes Mellitus

  • GDM

  • Diabetes Mellitus Arising In Pregnancy

  • Maternal Gestational Diabetes Mellitus

  • Diabetes Mellitus, Gestational

  • Diabetes Mellitus, Pregnancy Related

  • Diabetes, Pregnancy-Induced

  • Diabetes Gestational

  • Diabetes, Gestational

  • Diabetes Of Pregnancy

  • Gdm - [Gestational Diabetes Mellitus]

  • Gestational Diabetes Mellitus Nos

  • Gestational Diabetes Complicating Pregnancy, Childbirth, Or The Puerperium
Microinvasive Cervical Squamous Cell Carcinoma

  • Early Invasive Cervical Squamous Cell Carcinoma
Type 1 Diabetes Mellitus 5

  • Diabetes Mellitus, Insulin-Dependent, 5

  • Latent Autoimmune Diabetes In Adults

  • IDDM5

  • Insulin-Dependent Diabetes Mellitus 5

  • T1D5

  • Lada

  • Type 1.5 Diabetes

  • Diabetes Mellitus, Insulin-Dependent, Type 5
Pancreatic Cystadenoma

  • Cystadenoma Of Pancreas
Lymphocele

  • Lymph Cyst

  • Lymphocele Adverse Event
Common Peroneal Nerve Lesion

  • Lesion Of Lateral Popliteal Nerve

  • Fibular Neuropathy
Parametritis

  • Pelvic Cellulitis
Diabetes Mellitus, Ketosis-Prone

  • Diabetic Ketoacidosis

  • KPD

  • Diabetes Mellitus, Ketosis-Prone, Susceptibility To

  • Ketosis-Prone Diabetes Mellitus

  • Diabetes Mellitus, Insulin-Dependent

  • Diabetic Ketoacidosis Nos

  • Dka - [Diabetic Ketoacidosis] Nos

  • Dka - [Diabetic Ketoacidosis] Without Coma

  • Dka - [Diabetic Ketoacidosis] With Coma
Hemometra

  • Hematometra
Cervical Incompetence

  • Uterine Cervical Incompetence
Type 1 Diabetes Mellitus 7

  • Diabetes Mellitus, Insulin-Dependent, 7

  • Iddm7

  • Insulin-Dependent Diabetes Mellitus 7

  • T1D7
Pancreatic Colloid Cystadenoma

  • Mucinous Cystadenoma Of Pancreas
Wissler-Fanconi Syndrome

  • Wissler'S Syndrome

  • Wissler'S Subsepsis Allergica
Isthmus Cancer
Cervical Large Cell Neuroendocrine Carcinoma
Autoimmune Disease Of Endocrine System
Adenocarcinoma In Situ
Adrenal Cortical Hypofunction

  • Adrenal Cortical Insufficiency

  • Corticoadrenal Insufficiency
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Adenosquamous Carcinoma

  • Adenosquamous Cell Carcinoma

  • Mixed Adenocarcinoma And Squamous Carcinoma

  • Carcinoma Adenosquamous

  • Carcinoma, Adenosquamous
Gastrointestinal System Benign Neoplasm
Uterus Carcinoma In Situ
Pernicious Anemia

  • Anemia, Pernicious

  • Anemia Pernicious

  • Pernicious Anaemia

  • Addison'S Anaemia

  • Biermer'S Anaemia

  • Biermer'S Anemia

  • Acquired Pernicious Anemia

  • Addison-Biermer Anemia

  • Addisonian Anemia

  • Biermer Anemia

  • Biermer'S Disease

  • Juvenile Onset Pernicious Anemia

  • Biermer Disease

  • Biermer-Addison Disease
Cervix Uteri Carcinoma In Situ

  • Carcinoma In Situ Of Cervix

  • Carcinoma In Situ Of Uterine Cervix

  • Cervical Intraepithelial Neoplasia

  • Carcinoma Of Cervix Stage 0

  • Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia

  • Cervix Ca In Situ

  • Cin Iii

  • Cin Iii - Carcinoma In Situ Of Cervix

  • Cin Iii - Severe Dyskaryosis

  • Severe Dysplasia Of Cervix

  • Severe Dysplasia Of The Cervix Uteri

  • Squamous Intraepithelial Neoplasia, Grade Iii

  • Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Cervical Adenosquamous Carcinoma

  • Adenosquamous Carcinoma Of Cervix

  • Adenosquamous Cell Carcinoma Of The Cervix Uteri
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Fallopian Tube Endometrioid Adenocarcinoma

  • Endometrioid Carcinoma Of The Fallopian Tube

  • Fallopian Tube Endometrioid Cancer

  • Fallopian Tube Endometrioid Neoplasm

  • Fallopian Tube Endometrioid Tumor
Maturity-Onset Diabetes Of The Young, Type 3

  • Maturity-Onset Diabetes Of The Young Type 3

  • MODY3

  • Mody, Type Iii

  • Mody Type 3

  • Mody, Type 3

  • Maturity-Onset Diabetes Of The Young 3

  • Mody-3

  • Diabetes Of The Young, Maturity-Onset, Type 3
Cervix Carcinoma

  • Cancer Of Cervix

  • Carcinoma Of Cervix

  • Carcinoma Cervix Uteri

  • Carcinoma Of The Cervix Uteri
Permanent Neonatal Diabetes Mellitus

  • Pndm

  • Permanent Diabetes Mellitus Of Infancy

  • Pdmi

  • Neonatal Diabetes Mellitus, Permanent
Celiac Disease 1

  • Celiac Disease

  • Coeliac Disease

  • Celiac Sprue

  • Celiac Disease, Susceptibility To

  • Gluten-Sensitive Enteropathy

  • Nontropical Sprue

  • Sprue

  • CELIAC1

  • Celiac Disease, Susceptibility To, 1

  • Celiac Sprue 1

  • Celiac Sprue, Susceptibility To, 1

  • Gluten-Sensitive Enteropathy 1

  • Gluten-Sensitive Enteropathy, Susceptibility To, 1

  • Idiopathic Steatorrhea

  • Cœliac Disease

  • Gluten Intolerance

  • Gluten-Induced Enteropathy

  • Gluten Enteropathy

  • Celiac Disease, Susceptibility To, Type 1

  • Childhood Celiac Disease

  • Coeliac Rickets

  • Gee Disease

  • Gee-Herter Disease

  • Heubner-Herter Disease

  • Idiopathic Steatorrhoea

  • Thaysen'S Disease

  • Herter Gee Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11445 PTPRN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11444 PTPRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20475 Ptprn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26983 Ptprn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PTPRN RGD RGD:620777
Bos taurus PTPRN VGNC VGNC:33554
Canis familiaris PTPRN VGNC VGNC:45193
Macaca mulatta PTPRN VGNC VGNC:76620
Felis catus PTPRN VGNC VGNC:69178
Mus musculus PTPRN MGD MGI:102765
Others PTPRN NCBI