PTPRS - protein tyrosine phosphatase receptor type S Gene

Homo sapiens

Also known as R-PTP-S; PTPSIGMA; R-PTP-sigma

Gene ID: 5802 | Gene type: protein coding

About PTPRS

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:5,205,508-5,340,812 (from NCBI)

This gene has 9 transcripts (splice variants), 285 orthologues and 35 paralogues. Broad expression in fat (RPKM 30.9), brain (RPKM 23.8) and 23 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRS Products(7)

mRNA	Protein	Name
NM_001394011.1	NP_001380940.1	receptor-type tyrosine-protein phosphatase S isoform 5 precursor
NM_001394012.1	NP_001380941.1	receptor-type tyrosine-protein phosphatase S isoform 6 precursor
NM_001394013.1	NP_001380942.1	receptor-type tyrosine-protein phosphatase S isoform 7 precursor
NM_002850.4	NP_002841.3	receptor-type tyrosine-protein phosphatase S isoform 1 precursor
NM_130853.3	NP_570923.2	receptor-type tyrosine-protein phosphatase S isoform 3 precursor
NM_130854.3	NP_570924.2	receptor-type tyrosine-protein phosphatase S isoform 2 precursor
NM_130855.3	NP_570925.2	receptor-type tyrosine-protein phosphatase S isoform 4 precursor

PTPRS Protein Structure

I-set

fn3

Y_phosphatase

0
300
600
900
1200
1500
1800
1948 a.a.

Protein Preferred Names

Protein Names

receptor-type tyrosine-protein phosphatase S

protein tyrosine phosphatase PTPsigma

Related Diseases

Diseases

Alias

Nk-Cell Enteropathy

Pineal Region Meningioma

Pineal Meningioma

Ureterocele

Pineal Gland Cancer

Tumor Of The Pineal Region	Malignant Pineal Region Tumor
Malignant Tumor Of Pineal Gland	Neoplasm Of Pineal Gland
Neoplasm Of The Pineal Region	Pineal Body Neoplasm
Pineocytic Tumor	Malignant Neoplasm Of Pineal Gland
Pineal Gland Neoplasm	Pineocytoma

Pineal Parenchymal Tumor Of Intermediate Differentiation

Pineal Parenchymal Tumour Of Intermediate Differentiation	Pineal Parenchymal Tumors Of Intermediate Differentiation
Pptid

Papillary Ependymoma

Ependymoma Papillary

Cerebrovascular Benign Neoplasm

Papilloma Of Choroid Plexus

Choroid Plexus Papilloma	CPP
Childhood Choroid Plexus Papilloma	Papilloma Choroid Plexus
Papilloma, Choroid Plexus	Choroid Plexus Carcinoma

Pineoblastoma

Pineal Pnet	Pinealoma
Pineal Gland Neoplasm	Pineocytoma
Tumor Of The Pineal Region

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11449	PTPRS Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTPRS	MGD	MGI:97815
Bos taurus	PTPRS	VGNC	VGNC:33558
Canis familiaris	PTPRS	VGNC	VGNC:45198
Rattus norvegicus	PTPRS	RGD	RGD:3452
Felis catus	PTPRS	VGNC	VGNC:69181
Macaca mulatta	PTPRS	VGNC	VGNC:76622

Name
Email *

	Sorry, but the email address you supplied was invalid.