Rims1 - regulating synaptic membrane exocytosis 1 Gene

Also Known as Rim; RIM1; RIM1a; Serg1; Rab3ip1; RIM1alpha; C030033M19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 116837

Summary

Enables transmembrane transporter binding activity. A structural constituent of presynaptic active zone. Involved in neurotransmitter secretion; positive regulation of gene expression; and regulation of nervous system process. Acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter; regulation of long-term neuronal synaptic plasticity; and regulation of membrane potential. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in cone-rod dystrophy 7. Orthologous to human RIMS1 (regulating synaptic membrane exocytosis 1). [provided by Alliance of Genome Resources, Apr 2022]

Rims1 Products (5)

mRNA Protein Name
NM_001012623.4 NP_001012641.2 regulating synaptic membrane exocytosis protein 1 isoform 3
NM_001012624.4 NP_001012642.2 regulating synaptic membrane exocytosis protein 1 isoform 4
NM_001012625.4 NP_001012643.2 regulating synaptic membrane exocytosis protein 1 isoform 5
NM_053270.4 NP_444500.2 regulating synaptic membrane exocytosis protein 1 isoform 1
NM_183018.5 NP_898839.3 regulating synaptic membrane exocytosis protein 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12578829 MGI
enables structural constituent of presynaptic active zone IDA
IDA: Inferred from direct assay
21241895 MGI
enables structural constituent of presynaptic active zone IEP
IEP: Inferred from expression pattern
27537483 MGI
enables structural constituent of presynaptic active zone IMP
IMP: Inferred from mutant phenotype
21241895 MGI
enables transmembrane transporter binding IDA
IDA: Inferred from direct assay
20452978 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter IGI
IGI: Inferred from genetic interaction
17124501 MGI
acts upstream of or within neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
25730884 MGI
involved in positive regulation of excitatory postsynaptic potential IGI
IGI: Inferred from genetic interaction
21262469 MGI
involved in positive regulation of gene expression IGI
IGI: Inferred from genetic interaction
21262469 MGI
involved in positive regulation of inhibitory postsynaptic potential IGI
IGI: Inferred from genetic interaction
21262469 MGI
involved in presynaptic dense core vesicle exocytosis IDA
IDA: Inferred from direct assay
31679900 MGI
involved in presynaptic dense core vesicle exocytosis IEP
IEP: Inferred from expression pattern
31679900 MGI
involved in presynaptic dense core vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
31679900 MGI
involved in regulation of calcium-dependent activation of synaptic vesicle fusion IDA
IDA: Inferred from direct assay
21241895 MGI
involved in regulation of calcium-dependent activation of synaptic vesicle fusion IMP
IMP: Inferred from mutant phenotype
21241895 MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
11797010 MGI
acts upstream of or within regulation of membrane potential IDA
IDA: Inferred from direct assay
20452978 MGI
involved in spontaneous neurotransmitter secretion IGI
IGI: Inferred from genetic interaction
21262469 MGI
involved in synaptic vesicle docking IDA
IDA: Inferred from direct assay
21241895 MGI
involved in synaptic vesicle docking IMP
IMP: Inferred from mutant phenotype
21241895 MGI
involved in synaptic vesicle priming IDA
IDA: Inferred from direct assay
21262469 MGI
involved in synaptic vesicle priming IMP
IMP: Inferred from mutant phenotype
21262469 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
21262469 MGI
is active in GABA-ergic synapse IMP
IMP: Inferred from mutant phenotype
21262469 MGI
is active in extrinsic component of presynaptic active zone membrane IDA
IDA: Inferred from direct assay
29606581 MGI
is active in extrinsic component of presynaptic active zone membrane IMP
IMP: Inferred from mutant phenotype
29606581 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
21262469 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
21262469 MGI
located in inhibitory synapse IMP
IMP: Inferred from mutant phenotype
22753485 MGI
located in postsynaptic density IDA
IDA: Inferred from direct assay
17114649 MGI
is active in presynaptic active zone cytoplasmic component IDA
IDA: Inferred from direct assay
27537483 MGI
is active in presynaptic active zone cytoplasmic component IMP
IMP: Inferred from mutant phenotype
27537483 MGI
located in synapse IDA
IDA: Inferred from direct assay
19812333 MGI
located in vesicle IDA
IDA: Inferred from direct assay
19036990 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

regulating synaptic membrane exocytosis protein 1

  • Rab3 effector

  • Rab3 interacting protein 1

  • rab3-interacting molecule 1

  • regulating synaptic membrane exocytosis 1 beta

  • synaptic exocytosis regulator 1

Rims1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Rims1 Q99NE5 Fbxl20 Mus musculus Q9CZV8
Pull Down
17803915
Intra
Rims1 Q99NE5 Fbxl20 Mus musculus Q9CZV8
Anti Bait CoIP
17803915
Intra
Rims1 Q99NE5 Fbxl20 Mus musculus Q9CZV8
IF
17803915
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D1751 RIM-1 / Unkown
HY-RS11978 RIMS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rims1 NCBI NCBI:22999