Rims1 - regulating synaptic membrane exocytosis 1 Gene

Mus musculus

Also known as Rim; RIM1; RIM1a; Serg1; Rab3ip1; RIM1alpha; C030033M19Rik

Gene ID: 116837 | Gene type: protein coding

About Rims1

Summary

Enables transmembrane transporter binding activity. A structural constituent of presynaptic active zone. Involved in neurotransmitter secretion; positive regulation of gene expression; and regulation of nervous system process. Acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter; regulation of long-term neuronal synaptic plasticity; and regulation of membrane potential. Located in several cellular components, including GABA-ergic synapse; glutamatergic synapse; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in cone-rod dystrophy 7. Orthologous to human RIMS1 (regulating synaptic membrane exocytosis 1). [provided by Alliance of Genome Resources, Apr 2022]

Rims1 Products(5)

mRNA	Protein	Name
NM_001012623.4	NP_001012641.2	regulating synaptic membrane exocytosis protein 1 isoform 3
NM_001012624.4	NP_001012642.2	regulating synaptic membrane exocytosis protein 1 isoform 4
NM_001012625.4	NP_001012643.2	regulating synaptic membrane exocytosis protein 1 isoform 5
NM_053270.4	NP_444500.2	regulating synaptic membrane exocytosis protein 1 isoform 1
NM_183018.5	NP_898839.3	regulating synaptic membrane exocytosis protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12578829	MGI
enables structural constituent of presynaptic active zone	IDA IDA: Inferred from direct assay	21241895	MGI
enables structural constituent of presynaptic active zone	IEP IEP: Inferred from expression pattern	27537483	MGI
enables structural constituent of presynaptic active zone	IMP IMP: Inferred from mutant phenotype	21241895	MGI
enables transmembrane transporter binding	IDA IDA: Inferred from direct assay	20452978	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within calcium ion-regulated exocytosis of neurotransmitter	IGI IGI: Inferred from genetic interaction	17124501	MGI
acts upstream of or within neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	25730884	MGI
involved in positive regulation of excitatory postsynaptic potential	IGI IGI: Inferred from genetic interaction	21262469	MGI
involved in positive regulation of gene expression	IGI IGI: Inferred from genetic interaction	21262469	MGI
involved in positive regulation of inhibitory postsynaptic potential	IGI IGI: Inferred from genetic interaction	21262469	MGI
involved in presynaptic dense core vesicle exocytosis	IDA IDA: Inferred from direct assay	31679900	MGI
involved in presynaptic dense core vesicle exocytosis	IEP IEP: Inferred from expression pattern	31679900	MGI
involved in presynaptic dense core vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	31679900	MGI
involved in regulation of calcium-dependent activation of synaptic vesicle fusion	IDA IDA: Inferred from direct assay	21241895	MGI
involved in regulation of calcium-dependent activation of synaptic vesicle fusion	IMP IMP: Inferred from mutant phenotype	21241895	MGI
acts upstream of or within regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11797010	MGI
acts upstream of or within regulation of membrane potential	IDA IDA: Inferred from direct assay	20452978	MGI
involved in spontaneous neurotransmitter secretion	IGI IGI: Inferred from genetic interaction	21262469	MGI
involved in synaptic vesicle docking	IDA IDA: Inferred from direct assay	21241895	MGI
involved in synaptic vesicle docking	IMP IMP: Inferred from mutant phenotype	21241895	MGI
involved in synaptic vesicle priming	IDA IDA: Inferred from direct assay	21262469	MGI
involved in synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	21262469	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in GABA-ergic synapse	IDA IDA: Inferred from direct assay	21262469	MGI
is active in GABA-ergic synapse	IMP IMP: Inferred from mutant phenotype	21262469	MGI
is active in extrinsic component of presynaptic active zone membrane	IDA IDA: Inferred from direct assay	29606581	MGI
is active in extrinsic component of presynaptic active zone membrane	IMP IMP: Inferred from mutant phenotype	29606581	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21262469	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21262469	MGI
located in inhibitory synapse	IMP IMP: Inferred from mutant phenotype	22753485	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
is active in presynaptic active zone cytoplasmic component	IDA IDA: Inferred from direct assay	27537483	MGI
is active in presynaptic active zone cytoplasmic component	IMP IMP: Inferred from mutant phenotype	27537483	MGI
located in synapse	IDA IDA: Inferred from direct assay	19812333	MGI
located in vesicle	IDA IDA: Inferred from direct assay	19036990	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

regulating synaptic membrane exocytosis protein 1

Rab3 effector	Rab3 interacting protein 1
rab3-interacting molecule 1	regulating synaptic membrane exocytosis 1 beta
synaptic exocytosis regulator 1

Rims1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Rims1	Q99NE5	Fbxl20	Mus musculus	Q9CZV8	Pull Down	17803915
Intra	Rims1	Q99NE5	Fbxl20	Mus musculus	Q9CZV8	Anti Bait CoIP	17803915
Intra	Rims1	Q99NE5	Fbxl20	Mus musculus	Q9CZV8	IF	17803915

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D1751	RIM-1		/	Unkown
HY-RS11978	RIMS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rims1	NCBI	NCBI:22999

Name
Email *

	Sorry, but the email address you supplied was invalid.