Fbxl20 - F-box and leucine-rich repeat protein 20 Gene

Also Known as Scr; Fbl2; mKIAA4147; 2610511F20Rik; 4632423N09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 72194

Summary

Involved in regulation of protein catabolic process at presynapse, modulating synaptic transmission and regulation of synaptic vesicle exocytosis. Acts upstream of or within behavioral fear response. Located in Schaffer collateral - CA1 synapse. Is active in glutamatergic synapse. Is expressed in several structures, including adrenal gland; brain; genitourinary system; gut; and respiratory system. Orthologous to human FBXL20 (F-box and leucine rich repeat protein 20). [provided by Alliance of Genome Resources, Apr 2022]

Fbxl20 Products (1)

mRNA Protein Name
NM_028149.1 NP_082425.1 F-box/LRR-repeat protein 20

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17803915 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within behavioral fear response IMP
IMP: Inferred from mutant phenotype
21390313 MGI
involved in regulation of protein catabolic process at presynapse, modulating synaptic transmission IDA
IDA: Inferred from direct assay
17803915 MGI
involved in regulation of protein catabolic process at presynapse, modulating synaptic transmission IEP
IEP: Inferred from expression pattern
17803915 MGI
involved in regulation of protein catabolic process at presynapse, modulating synaptic transmission IMP
IMP: Inferred from mutant phenotype
17803915 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
17803915 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
17803915 MGI
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
17803915 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
17803915 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17803915 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
17803915 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17803915 MGI
is active in synapse IDA
IDA: Inferred from direct assay
17803915 MGI
is active in synapse IEP
IEP: Inferred from expression pattern
17803915 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 20

  • scrapper

Fbxl20 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fbxl20 Q9CZV8 Rims1 Mus musculus Q99NE5
Pull Down
17803915
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04790 FBXL20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbxl20 NCBI NCBI:84961