Alox8 - arachidonate 8-lipoxygenase Gene

Also Known as 8-LOX; 8S-LOX; Alox15b; 15-LOX-2; 15-LOX-B

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11688

Summary

This gene belongs to the Lipoxygenase (LOX) gene family whose members encode Enzymes that catalyze the addition of molecular oxygen to polyunsaturated fatty acids (PUFAs) to yield fatty acid hydroperoxides. The encoded enzyme preferentially metabolizes arachidonic acid to yield 8-hydroxyeicosatetraenoic acid (8-HETE), while metabolizing linoleic acid less efficiently. The gene may also function as a tumor suppressor. This gene is located in a cluster of related genes that spans approximately 75 kilobases on chromosome 11. [provided by RefSeq, Jan 2013]

Alox8 Products (1)

mRNA Protein Name
NM_009661.4 NP_033791.1 polyunsaturated fatty acid lipoxygenase ALOX8

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables arachidonate 15-lipoxygenase activity IDA
IDA: Inferred from direct assay
27435673 MGI
enables arachidonate 8(S)-lipoxygenase activity IDA
IDA: Inferred from direct assay
9305900 MGI
enables linoleate 9S-lipoxygenase activity IDA
IDA: Inferred from direct assay
9305900 MGI
Biological Process GO Annotation Evidence References Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
9305900 MGI
involved in linoleic acid metabolic process IDA
IDA: Inferred from direct assay
9305900 MGI
involved in lipoxygenase pathway IDA
IDA: Inferred from direct assay
9305900 MGI
involved in phospholipid metabolic process IDA
IDA: Inferred from direct assay
27435673 MGI
involved in positive regulation of keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
10965849 MGI
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10965849 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyunsaturated fatty acid lipoxygenase ALOX8

  • 15-lipoxygenase 2

  • 8S-lipoxygenase

  • arachidonate 15-lipoxygenase B

  • arachidonate 15-lipoxygenase type II

  • arachidonate 15-lipoxygenase, second type

  • arachidonate 8S-lipoxygenase

  • linoleate 9S-lipoxygenase ALOX8

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143787 ALOX15-IN-1 Inhibitor 98.01% Unkown
HY-143791 ALOX15-IN-2 Inhibitor 99.88% Unkown
HY-RS00613 Alox12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00616 ALOX15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00619 ALOX15B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00620 ALOX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00625 Alox5ap Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-175634 ALOX5 stabilizer-1 / Unkown
HY-175634A ALOX5 stabilizer-1 TFA / Unkown
HY-RS00612 ALOX12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00614 Alox12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00615 ALOX12B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00617 Alox15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00618 Alox15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00621 Alox5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00622 Alox5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00623 ALOX5AP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00624 Alox5ap Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00626 ALOXE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27130 Alox15b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown