ACAP3 - ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 Gene

Also Known as CENTB5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 116983

About ACAP3

This gene has 13 transcripts (splice variants), 274 orthologues and 28 paralogues. Ubiquitous expression in skin (RPKM 16.2), brain (RPKM 12.8) and 24 other tissues.

Summary

Predicted to enable GTPase activator activity and metal ion binding activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within neuron migration and regulation of neuron projection development. Predicted to be located in growth cone. [provided by Alliance of Genome Resources, Apr 2022]

ACAP3 Products (1)

mRNA	Protein	Name
NM_030649.3	NP_085152.2	arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACAP3 Protein Structure

PH

ArfGap

Ank_2

0
200
400
600
834 a.a.

Protein Preferred Names	Protein Names
arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3	centaurin-beta-5

ACAP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ACAP3	Q96P50	ACAP2	Homo sapiens	Q15057	Anti Tag CoIP	35271311
Intra	ACAP3	Q96P50	ACAP2	Homo sapiens	Q15057	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Osteosclerotic Myeloma
Brachial Plexus Neuritis	Brachial Neuritis Parsonage-Aldren-Turner Syndrome
Recessive Dystrophic Epidermolysis Bullosa	Autosomal Recessive Dystrophic Epidermolysis Bullosa Generalisata Gravis Autosomal Recessive Dystrophic Epidermolysis Bullosa, Hallopeau-Siemens Type Rdeb, Hallopeau-Siemens Type Severe Generalized Rdeb Severe Generalized Recessive Dystrophic Epidermolysis Bullosa Rdeb Generalisata Gravis Rdeb, Severe Generalized Rdeb-Sev Gen Recessive Dystrophic Epidermolysis Bullosa, Severe Generalized Hallopeau-Siemens Disease
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00135	ACAP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ACAP3	VGNC	VGNC:59499
Canis familiaris	ACAP3	VGNC	VGNC:37497
Bos taurus	ACAP3	VGNC	VGNC:25528
Mus musculus	ACAP3	MGD	MGI:2153589
Rattus norvegicus	ACAP3	RGD	RGD:1310711
Macaca mulatta	ACAP3	VGNC	VGNC:69434
Others	ACAP3	NCBI