ACAP2 - ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 Gene

Also Known as CENTB2; CNT-B2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23527

About ACAP2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,274,745-195,443,020 (from NCBI)

This gene has 15 transcripts (splice variants), 212 orthologues and 28 paralogues. Ubiquitous expression in thyroid (RPKM 13.3), lymph node (RPKM 12.2) and 25 other tissues.

Summary

Enables GTPase activator activity. Acts upstream of or within actin filament-based process. Located in ruffle. [provided by Alliance of Genome Resources, Apr 2022]

ACAP2 Products (1)

mRNA Protein Name
NM_012287.6 NP_036419.3 arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
11062263 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
33961781 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin filament-based process IDA
IDA: Inferred from direct assay
11062263 GOA
Cellular Component GO Annotation Evidence References Source
located in ruffle IDA
IDA: Inferred from direct assay
11062263 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACAP2 Protein Structure

PH

PH: PH domain (268 - 359)

ArfGap

ArfGap: Putative GTPase activating protein for Arf (400 - 515)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (613 - 704)

  • 0
  • 200
  • 400
  • 600
  • 778 a.a.
Protein Preferred Names Protein Names

arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

  • Arf GAP with coiled coil, ANK repeat and PH domains 2

ACAP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACAP2 Q15057 ACAP3 Homo sapiens Q96P50
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

ACAP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82740 ACAP2 Antibody (YA2485) WB Human, Hamster, Rat
HY-P82740A ACAP2 Antibody (YA2485)(PBS only) WB Human, Hamster, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00134 ACAP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACAP2 MGD MGI:1925868
Canis familiaris ACAP2 VGNC VGNC:53055
Felis catus ACAP2 VGNC VGNC:59498
Rattus norvegicus ACAP2 RGD RGD:1562939
Bos taurus ACAP2 VGNC VGNC:25527
Macaca mulatta ACAP2 VGNC VGNC:69428
Others ACAP2 NCBI