Ank - progressive ankylosis Gene

Also Known as ank; Ankh; mKIAA1581; D15Ertd221e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11732

Summary

Enables inorganic diphosphate transmembrane transporter activity. Acts upstream of or within regulation of bone mineralization. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including bone; connective tissue; olfactory epithelium; telencephalon; and vibrissa follicle. Used to study craniometaphyseal dysplasia. Human ortholog(s) of this gene implicated in autosomal dominant craniometaphyseal dysplasia and chondrocalcinosis. Orthologous to human ANKH (ANKH inorganic pyrophosphate transport regulator). [provided by Alliance of Genome Resources, Apr 2022]

Ank Products (1)

mRNA Protein Name
NM_020332.4 NP_065065.3 progressive ankylosis protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables inorganic diphosphate transmembrane transporter activity IDA
IDA: Inferred from direct assay
10894769 MGI
Biological Process GO Annotation Evidence References Source
involved in bone mineralization IDA
IDA: Inferred from direct assay
12817751 MGI
involved in bone mineralization IMP
IMP: Inferred from mutant phenotype
12817751 MGI
involved in calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
12817751 MGI
involved in cementum mineralization IDA
IDA: Inferred from direct assay
31059863 MGI
involved in cementum mineralization IMP
IMP: Inferred from mutant phenotype
31059863 MGI
involved in diphosphate metabolic process IDA
IDA: Inferred from direct assay
31059863 MGI
involved in diphosphate metabolic process IMP
IMP: Inferred from mutant phenotype
31059863 MGI
involved in gene expression IDA
IDA: Inferred from direct assay
31059863 MGI
involved in gene expression IMP
IMP: Inferred from mutant phenotype
12817751 MGI
involved in inhibition of non-skeletal tissue mineralization IDA
IDA: Inferred from direct assay
21490328 MGI
involved in inhibition of non-skeletal tissue mineralization IMP
IMP: Inferred from mutant phenotype
15625282 MGI
involved in inorganic diphosphate transport IMP
IMP: Inferred from mutant phenotype
15625282 MGI
involved in muscle cell cellular homeostasis IMP
IMP: Inferred from mutant phenotype
15625282 MGI
involved in phosphate ion homeostasis IMP
IMP: Inferred from mutant phenotype
12817751 MGI
acts upstream of or within regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
7276519 MGI
involved in regulation of bone mineralization IMP
IMP: Inferred from mutant phenotype
10894769 MGI
involved in response to sodium phosphate IMP
IMP: Inferred from mutant phenotype
12817751 MGI
Cellular Component GO Annotation Evidence References Source
is active in extracellular region IMP
IMP: Inferred from mutant phenotype
12817751 MGI
located in membrane IDA
IDA: Inferred from direct assay
11326272 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
10894769 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

progressive ankylosis protein

  • fn54 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00735 ANKS1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10844 ANK peptide / Unkown
HY-RS00699 ANK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00700 ANK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00701 ANK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00706 ANKH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00736 ANKS1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00737 ANKS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19574 Ank3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24706 Ankh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26071 Ank3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992043 Tolododekin alfa Modulator / Unkown