Ank - progressive ankylosis Gene

Mus musculus

Also known as ank; Ankh; mKIAA1581; D15Ertd221e

Gene ID: 11732 | Gene type: protein coding

About Ank

Summary

Enables inorganic diphosphate transmembrane transporter activity. Acts upstream of or within regulation of bone mineralization. Located in plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including bone; connective tissue; olfactory epithelium; telencephalon; and vibrissa follicle. Used to study craniometaphyseal dysplasia. Human ortholog(s) of this gene implicated in autosomal dominant craniometaphyseal dysplasia and chondrocalcinosis. Orthologous to human ANKH (ANKH inorganic pyrophosphate transport regulator). [provided by Alliance of Genome Resources, Apr 2022]

Ank Products(1)

mRNA	Protein	Name
NM_020332.4	NP_065065.3	progressive ankylosis protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables inorganic diphosphate transmembrane transporter activity	IDA IDA: Inferred from direct assay	10894769	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in bone mineralization	IDA IDA: Inferred from direct assay	12817751	MGI
involved in bone mineralization	IMP IMP: Inferred from mutant phenotype	12817751	MGI
involved in calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	12817751	MGI
involved in cementum mineralization	IDA IDA: Inferred from direct assay	31059863	MGI
involved in cementum mineralization	IMP IMP: Inferred from mutant phenotype	31059863	MGI
involved in diphosphate metabolic process	IDA IDA: Inferred from direct assay	31059863	MGI
involved in diphosphate metabolic process	IMP IMP: Inferred from mutant phenotype	31059863	MGI
involved in gene expression	IDA IDA: Inferred from direct assay	31059863	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	12817751	MGI
involved in inhibition of non-skeletal tissue mineralization	IDA IDA: Inferred from direct assay	21490328	MGI
involved in inhibition of non-skeletal tissue mineralization	IMP IMP: Inferred from mutant phenotype	15625282	MGI
involved in inorganic diphosphate transport	IMP IMP: Inferred from mutant phenotype	15625282	MGI
involved in muscle cell cellular homeostasis	IMP IMP: Inferred from mutant phenotype	15625282	MGI
involved in phosphate ion homeostasis	IMP IMP: Inferred from mutant phenotype	12817751	MGI
acts upstream of or within regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	7276519	MGI
involved in regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	10894769	MGI
involved in response to sodium phosphate	IMP IMP: Inferred from mutant phenotype	12817751	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in extracellular region	IMP IMP: Inferred from mutant phenotype	12817751	MGI
located in membrane	IDA IDA: Inferred from direct assay	11326272	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	10894769	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

progressive ankylosis protein

fn54 protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00735	ANKS1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P10844	ANK peptide		/	Unkown
HY-RS00699	ANK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00700	ANK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00701	ANK3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00706	ANKH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00736	ANKS1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS00737	ANKS6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19574	Ank3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24706	Ankh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26071	Ank3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992043	Tolododekin alfa	Modulator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca fascicularis	Ank	NCBI
Rattus norvegicus	Ank	NCBI

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