2. Immunology/Inflammation
  3. Interleukin Related PD-1/PD-L1
  4. Tolododekin alfa

Tolododekin alfa  (Synonyms: ANK-101)

Cat. No.: HY-P992043
Technical Support

Tolododekin alfa (ANK-101) is a drug conjugate that anchors and combines IL-12 with Aluminum Hydroxide (HY-B1521). Tolododekin alfa promotes the recruitment of effector CD8+ T cells to tumor sites, enhances the production of γ-interferon, upregulates the expression of PD-L1, and induces sustained pro-inflammatory gene expression in mouse tumor models. Tolododekin alfa can be used for research related to advanced solid tumors.

For research use only. We do not sell to patients.

Tolododekin alfa

Tolododekin alfa Chemical Structure

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Tolododekin alfa Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

Tolododekin alfa (ANK-101) is a drug conjugate that anchors and combines IL-12 with Aluminum Hydroxide (HY-B1521). Tolododekin alfa promotes the recruitment of effector CD8+ T cells to tumor sites, enhances the production of γ-interferon, upregulates the expression of PD-L1, and induces sustained pro-inflammatory gene expression in mouse tumor models. Tolododekin alfa can be used for research related to advanced solid tumors[1].

Species Reactivity

Human
IC50 & Target[1]

IL-12

 

In Vivo

Tolododekin alfa persists in mouse tumors for several weeks with no signs of toxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Gene ID

3595  [NCBI]

Accession

Q99665
Target

IL12RB2
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[Tolododekin alfa]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Tolododekin alfa Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tolododekin alfaANK-101ANK101ANK 101Interleukin RelatedPD-1/PD-L1ILPD-1/Programmed death-ligand 1aluminum hydroxideInterleukin 12interferon-γCD8+ T cellsPD-L1murine tumor modelsInhibitorinhibitorinhibit

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