IL12RB2 - interleukin 12 receptor subunit beta 2 Gene

Homo sapiens

Gene ID: 3595 | Gene type: protein coding

About IL12RB2

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:67,307,364-67,398,724 (from NCBI)

This gene has 18 transcripts (splice variants), 200 orthologues and 23 paralogues. Broad expression in placenta (RPKM 2.3), brain (RPKM 0.9) and 18 other tissues.

Summary

The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]

IL12RB2 Products(6)

mRNA	Protein	Name
NM_001258214.1	NP_001245143.1	interleukin-12 receptor subunit beta-2 isoform b precursor
NM_001258215.1	NP_001245144.1	interleukin-12 receptor subunit beta-2 isoform c precursor
NM_001258216.1	NP_001245145.1	interleukin-12 receptor subunit beta-2 isoform d precursor
NM_001319233.1	NP_001306162.1	interleukin-12 receptor subunit beta-2 isoform b precursor
NM_001374259.2	NP_001361188.1	interleukin-12 receptor subunit beta-2 isoform a precursor
NM_001559.3	NP_001550.1	interleukin-12 receptor subunit beta-2 isoform a precursor

IL12RB2 Protein Structure

Lep_receptor_Ig

IL6Ra-bind

fn3

0
200
400
600
800
862 a.a.

Protein Preferred Names

Protein Names

interleukin-12 receptor subunit beta-2

IL-12 receptor subunit beta-2

Related Diseases

Diseases

Alias

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Immunodeficiency 30

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Il12rb1 Deficiency	IMD30
Il12rb1 Deficiency	Mendelian Susceptibility To Interleukin 12 Receptor Beta 1 Deficiency
Msmd Due To Complete Il12rb1 Deficiency	Msmd Due To Complete Interleukin 12 Receptor Beta 1 Deficiency
Il-12râ1 Deficiency	Mendelian Susceptibility To Mycobacterial Infections Due To Il12 Deficiency
Immunodeficiency, Type 30

Smallpox

Variola	Ordinary Smallpox
Alastrim	Amaas

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Mumps

Parotitis Due To Mumps Virus	Mumps Nos
Epidemic Parotitis	Infectious Parotitis

Rubella

German Measles	Three Day Measles
Rubella Nos

Takayasu Arteritis

Aortic Arch Syndrome	Pulseless Disease
Takayasu'S Arteritis	Idiopathic Aortitis
Young Female Arteritis	Aortic Arch Arteritis
Aortic Arches Defect	Aortic Arch Defects
Takayasu Disease	Aortic Arch Syndromes
Takayasu'S Disease	Ta
Obliterative Aortitis	Aortic Arch Giant-Cell Arteritis
Subclavian-Carotid Obstruction Syndrome	Idiopathic Medial Aortopathy And Arteriopathy
Takayasu Syndrome	Obliterative Brachiocephalic Arteritis Syndrome
Raeder-Harbitz Syndrome	Chronic Subclavian-Carotid Obstruction Syndrome
Giant-Cell Aortitis	Takayasu Aortitis
Nonspecific Aortoarteritis	Sclerosing Aortitis And Arteritis
Martorell 2 Syndrome	Young Female Aortic Arch Arteritis Syndrome

Inflammatory Bowel Disease 23

IBD23

Familial Behcet-Like Autoinflammatory Syndrome

Autoinflammatory Syndrome, Familial, Behcet-Like

A20 Haploinsufficiency

Autoimmune Cholangitis

Autoimmune Cholangiopathy

Sarcoidosis 1

Sarcoidosis	Boeck Sarcoid
Besnier-Boeck-Schaumann Disease	SS1
Sarcoidosis, Susceptibility To, 1	Lymphogranulomatosis
Hodgkin Disease	Boeck'S Disease
Boeck'S Sarcoid	Schaumann'S Disease Or Syndrome
Hutchinson-Boeck Disease Or Syndrome

Aphthous Stomatitis

Oral Ulcer	Canker Sore
Aphtha	Aphthous Ulceration
Oral Aphthae	Oral Aphthous Ulcer
Canker Sores	Stomatitis, Aphthous
Minor Oral Aphthous Ulceration

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behçet'S Disease
Behet'S Syndrome	Bd Syndrome
Behçet Syndrome	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06684	IL12RB2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IL12RB2	MGD	MGI:1270861
Bos taurus	IL12RB2	VGNC	VGNC:30113
Macaca mulatta	IL12RB2	VGNC	VGNC:73708
Rattus norvegicus	IL12RB2	RGD	RGD:620026
Felis catus	IL12RB2	VGNC	VGNC:67757
Canis familiaris	IL12RB2	VGNC	VGNC:41935

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