Ap2a2 - adaptor-related protein complex 2, alpha 2 subunit Gene

Also Known as L25; Adtab; 2410074K14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11772

Summary

Enables disordered domain specific binding activity and protein kinase binding activity. Involved in clathrin-dependent endocytosis. Located in cytoplasmic vesicle. Part of AP-2 adaptor complex. Is expressed in brain. Orthologous to human AP2A2 (adaptor related protein complex 2 subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Ap2a2 Products (2)

mRNA Protein Name
NM_001357068.1 NP_001343997.1 AP-2 complex subunit alpha-2 isoform 1
NM_007459.3 NP_031485.3 AP-2 complex subunit alpha-2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables disordered domain specific binding IPI
IPI: Inferred from physical interaction
11756460 MGI
enables kinase binding IPI
IPI: Inferred from physical interaction
17880279 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11470803 MGI
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
12732633 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21307259 MGI
Biological Process GO Annotation Evidence References Source
involved in clathrin-dependent endocytosis IDA
IDA: Inferred from direct assay
23676497 MGI
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
35014951 MGI
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
35014951 MGI
Cellular Component GO Annotation Evidence References Source
part of AP-2 adaptor complex IDA
IDA: Inferred from direct assay
23676497 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
22174158 MGI
part of membrane coat IDA
IDA: Inferred from direct assay
11879655 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

AP-2 complex subunit alpha-2

  • 100 kDa coated vesicle protein C

  • adapter-related protein complex 2 alpha-2 subunit

  • adapter-related protein complex 2 subunit alpha-2

  • adaptor protein complex AP-2 subunit alpha-2

  • adaptor protein complex AP-2, alpha 2 subunit

  • adaptor-related protein co

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2259 TAT-GluA2 3Y Inhibitor 99.93% Unkown
HY-W923189 Neral 97.87% Unkown
HY-159931 HW161023 Inhibitor / Unkown
HY-RS00785 AP2A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-159879 AAK1-IN-6 Inhibitor / Unkown
HY-174213 AAK1-IN-7 Inhibitor / Unkown
HY-174214 AAK1-IN-8 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ap2a2 NCBI NCBI:161