Rhob - ras homolog family member B Gene

Mus musculus

Also known as Arh6; Arhb

Gene ID: 11852 | Gene type: protein coding

About Rhob

Summary

Enables GDP binding activity. Involved in several processes, including negative regulation of cell cycle; positive regulation of angiogenesis; and positive regulation of apoptotic process. Acts upstream of or within intracellular protein transport. Located in endosome; nucleus; and plasma membrane. Is expressed in several structures, including branchial arch; embryo ectoderm; heart; nervous system; and otocyst. Orthologous to human RHOB (Ras homolog family member B). [provided by Alliance of Genome Resources, Apr 2022]

Rhob Products(1)

mRNA	Protein	Name
NM_007483.3	NP_031509.1	rho-related GTP-binding protein RhoB

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	8939998	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	8543060	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell adhesion	IDA IDA: Inferred from direct assay	11564874	MGI
acts upstream of or within intracellular protein transport	IMP IMP: Inferred from mutant phenotype	17623777	MGI
involved in negative regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	11564874	MGI
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	14597666	MGI
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	11353846	MGI
involved in regulation of modification of postsynaptic structure	IDA IDA: Inferred from direct assay	20203211	MGI
involved in regulation of modification of postsynaptic structure	IMP IMP: Inferred from mutant phenotype	20203211	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	20203211	MGI
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	20203211	MGI
located in early endosome	IDA IDA: Inferred from direct assay	17623777	MGI
located in late endosome	IDA IDA: Inferred from direct assay	17623777	MGI
located in membrane	IDA IDA: Inferred from direct assay	8939998	MGI
located in nucleus	IDA IDA: Inferred from direct assay	14597666	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	15093731	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rho-related GTP-binding protein RhoB

aplysia ras-related homolog B	ras homolog B
ras homolog gene family, member AB	ras homolog gene family, member B

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-176902	NSC126188		/	Unkown
HY-28099	VEC6		/	Unkown
HY-RS11946	RHOB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rhob	NCBI	NCBI:388

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