Neurog3 - neurogenin 3 Gene

Also Known as ngn3; Atoh5; Math4B; bHLHa7

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11925

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in positive regulation of transcription, DNA-templated and transdifferentiation. Acts upstream of or within epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of dendrite morphogenesis. Located in nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; gut; and nervous system. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to human NEUROG3 (neurogenin 3). [provided by Alliance of Genome Resources, Apr 2022]

Neurog3 Products (1)

mRNA Protein Name
NM_009719.6 NP_033849.3 neurogenin-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
19759004 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
16511571 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16511571 MGI
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
16511571 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
18560595 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
12080087 MGI
acts upstream of or within multicellular organism development IMP
IMP: Inferred from mutant phenotype
12080087 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19759004 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16511571 MGI
acts upstream of or within regulation of dendrite morphogenesis IGI
IGI: Inferred from genetic interaction
21818269 MGI
involved in transdifferentiation IDA
IDA: Inferred from direct assay
16511571 MGI
Cellular Component GO Annotation Evidence References Source
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
10868931 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12921743 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurogenin-3

  • Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B)

  • atonal homolog 5

  • helix-loop-helix protein mATH-4B

  • protein atonal homolog 5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09230 NEUROG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174570 Human NEUROG3 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Neurog3 NCBI NCBI:50674