NEUROG3 - neurogenin 3 Gene

Also Known as ngn3; Atoh5; NGN-3; Math4B; bHLHa7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50674

About NEUROG3

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,571,485-69,573,422 (from NCBI)

This gene has 1 transcript (splice variant), 162 orthologues, 15 paralogues and is associated with 2 phenotypes. Biased expression in duodenum (RPKM 1.5), small intestine (RPKM 0.6) and 2 other tissues.

Summary

The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]

NEUROG3 Products (1)

mRNA Protein Name
NM_020999.4 NP_066279.2 neurogenin-3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
14576336 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
14576336 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
14576336 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16511571 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
20807725 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NEUROG3 Protein Structure

HLH

HLH: Helix-loop-helix DNA-binding domain (84 - 135)

  • 0
  • 100
  • 200
  • 214 a.a.
Protein Preferred Names Protein Names

neurogenin-3

  • class A basic helix-loop-helix protein 7

NEUROG3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NEUROG3 Q9Y4Z2 TCF12 Homo sapiens Q99081-3
Anti Tag CoIP
28514442
Intra
NEUROG3 Q9Y4Z2 TCF12 Homo sapiens Q99081-3
Y2H Array
25910212
Intra
NEUROG3 Q9Y4Z2 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra
NEUROG3 Q9Y4Z2 TCF12 Homo sapiens Q99081-3
Validated Y2H
25910212
Intra
NEUROG3 Q9Y4Z2 TCF12 Homo sapiens Q99081-3
Y2H Bait-Prey Pool
25910212
Intra
NEUROG3 Q9Y4Z2 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra
NEUROG3 Q9Y4Z2 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
NEUROG3 Q9Y4Z2 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
NEUROG3 Q9Y4Z2 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra
NEUROG3 Q9Y4Z2 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra
NEUROG3 Q9Y4Z2 REL Homo sapiens Q04864
Y2H Array
25416956
Intra
NEUROG3 Q9Y4Z2 TCF12 Homo sapiens Q99081
Y2H Prey Pooling
25416956
Intra
NEUROG3 Q9Y4Z2 TCF12 Homo sapiens Q99081
Y2H Array
25416956
Intra
NEUROG3 Q9Y4Z2 TCF12 Homo sapiens Q99081
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

NEUROG3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85295 Neurogenin 3 Antibody (YA4987) WB Human

Related Diseases

Diseases Alias
Diarrhea 4, Malabsorptive, Congenital

  • Enteric Anendocrinosis

  • Congenital Malabsorptive Diarrhea 4

  • DIAR4

  • Congenital Malabsorptive Diarrhea Due To Paucity Of Enteroendocrine Cells

  • Congenital Malabsorptive Diarrhoea 4

  • Congenital Malabsorptive Diarrhoea Due To Paucity Of Enteroendocrine Cells

  • Diarrhea, Type 4, Malabsorptive, Congenital
Hyperglycemia
Diarrhea

  • Diarrhoea

  • Diarrhea Of Presumed Infectious Origin
Pancreatic Agenesis

  • Partial Pancreatic Agenesis

  • Congenital Pancreatic Agenesis

  • Partial Agenesis Of The Pancreas

  • Agenesis, Pancreatic

  • Pancreatic Agenesis, Congenital
Proprotein Convertase 1/3 Deficiency

  • Obesity Due To Prohormone Convertase I Deficiency

  • Obesity With Impaired Prohormone Processing

  • Obesity And Endocrinopathy Due To Impaired Processing Of Prohormones

  • Pci Deficiency

  • Proprotein Convertase 1 3 Deficiency

  • Endocrinopathy Due To Proprotein Convertase 1/3 Deficiency

  • Proprotein Convertase 1 Deficiency

  • PC1 DEFICIENCY
Glucose Intolerance

  • Glucose: Intolerance

  • Glucose: Malabsorption

  • Malabsorption Of Glucose

  • Impaired Glucose Tolerance
Insulinoma

  • Islet Cell Adenoma

  • Insulin-Producing Tumor Of Islet Cells

  • Adenoma Islet Cell

  • Islet Cell Tumor

  • Experimental Organism Islet Cell Adenoma Neoplasm
Diarrhea 5, With Tufting Enteropathy, Congenital

  • Congenital Diarrhea 5 With Tufting Enteropathy

  • Congenital Tufting Enteropathy

  • DIAR5

  • Cte

  • Intestinal Epithelial Cell Dysplasia

  • Tufting Enteropathy

  • Ied

  • Intestinal Epithelial Dysplasia

  • Enteropathy, Congenital Tufting

  • Congenital Diarrhoea 5 With Tufting Enteropathy

  • Congenital Familial Intractable Diarrhea With Epithelial Or Epithelium Abnormalities

  • Congenital Familial Intractable Diarrhoea With Epithelial Or Epithelium Abnormalities

  • Congenital Enteropathy

  • Congenital Familial Intractable Diarrhea With Enterocytes Assembly Abnormalities

  • Non-Syndromic Congenital Tufting Enteropathy

  • Diarrhea, Type 5, With Tufting Enteropathy, Congenital

  • Intestinal Intraepithelial Neoplasia
Neonatal Diabetes

  • Neonatal Diabetes Mellitus

  • Diabetes Mellitus Syndrome In Newborn Infant

  • Ndm
Congenital Diarrhea
Diarrhea 8, Secretory Sodium, Congenital

  • Congenital Secretory Sodium Diarrhea 8

  • DIAR8

  • Diarrhea, Congenital Sodium

  • Csd

  • Congenital Secretory Diarrhea, Sodium Type
Permanent Neonatal Diabetes Mellitus

  • Pndm

  • Permanent Diabetes Mellitus Of Infancy

  • Pdmi

  • Neonatal Diabetes Mellitus, Permanent
Maturity-Onset Diabetes Of The Young, Type 4

  • Maturity-Onset Diabetes Of The Young Type 4

  • MODY4

  • Mody, Type Iv

  • Mody Type 4

  • Mody, Type 4

  • Maturity-Onset Diabetes Of The Young 4

  • Mody-4

  • Diabetes Of The Young, Maturity-Onset, Type 4

  • Maturity-Onset Diabetes Of The Young, Type Iv
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Intestinal Atresia
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Pancreatic Cystadenoma

  • Cystadenoma Of Pancreas
Maturity-Onset Diabetes Of The Young, Type 1

  • Maturity-Onset Diabetes Of The Young Type 1

  • MODY1

  • Mild Juvenile Diabetes Mellitus

  • Mody, Type I

  • Diabetes Mellitus Type 2

  • Mody Type 1

  • Mody, Type 1

  • Maturity-Onset Diabetes Of The Young 1

  • Mody-1

  • Diabetes Of The Young, Maturity-Onset, Type 1
Maturity-Onset Diabetes Of The Young, Type 3

  • Maturity-Onset Diabetes Of The Young Type 3

  • MODY3

  • Mody, Type Iii

  • Mody Type 3

  • Mody, Type 3

  • Maturity-Onset Diabetes Of The Young 3

  • Mody-3

  • Diabetes Of The Young, Maturity-Onset, Type 3
Transient Neonatal Diabetes Mellitus

  • Diabetes Mellitus, Transient Neonatal

  • Tndm

  • Chromosome 6-Associated Transient Diabetes Mellitus

  • Dmtn

  • Diabetes Mellitus, 6q24-Related Transient Neonatal

  • Tndm1

  • Neonatal Diabetes Mellitus, Transient

  • Tndm -[Transient Neonatal Diabetes Mellitus]
Microvillus Inclusion Disease

  • Congenital Microvillous Atrophy

  • Intractable Diarrhea Of Infancy

  • Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities

  • Davidson Disease

  • Microvillous Inclusion Disease

  • Congenital Microvillus Atrophy

  • Mvid

  • Diarrhea 2 With Microvillus Atrophy

  • Mvd

  • Congenital Familial Protracted Diarrhea

  • Davidson'S Disease

  • Familial Enteropathy, Microvillus

  • Microvillus Atrophy, Congenital

  • Congenital Enteropathy

  • Familial Protracted Enteropathy

  • Microvillous Atrophy

  • Microvillus Atrophy With Diarrhea 2

  • Idi
Diabetes Mellitus

  • Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09230 NEUROG3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174570 Human NEUROG3 mRNA / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NEUROG3 VGNC VGNC:75171
Mus musculus NEUROG3 MGD MGI:893591
Bos taurus NEUROG3 VGNC VGNC:32023
Canis familiaris NEUROG3 VGNC VGNC:43758
Rattus norvegicus NEUROG3 RGD RGD:631350
Others NEUROG3 NCBI