IFTAP - intraflagellar transport associated protein Gene

Also Known as NWC; HEPIS; C11orf74

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 119710

About IFTAP

Cytogenetic location: 11p12 Genomic coordinates (GRCh38): 11:36,594,502-36,659,272 (from NCBI)

This gene has 27 transcripts (splice variants) and 123 orthologues. Broad expression in thyroid (RPKM 26.2), testis (RPKM 16.8) and 22 other tissues.

Summary

This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

IFTAP Products (7)

mRNA Protein Name
NM_001276722.2 NP_001263651.1 intraflagellar transport-associated protein isoform a
NM_001276723.2 NP_001263652.1 intraflagellar transport-associated protein isoform a
NM_001276724.2 NP_001263653.1 intraflagellar transport-associated protein isoform a
NM_001276725.2 NP_001263654.1 intraflagellar transport-associated protein isoform b
NM_001276726.2 NP_001263655.1 intraflagellar transport-associated protein isoform b
NM_001276727.2 NP_001263656.1 intraflagellar transport-associated protein isoform b
NM_138787.4 NP_620142.2 intraflagellar transport-associated protein isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables intraciliary transport particle A binding IDA
IDA: Inferred from direct assay
30476139 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18433331 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

intraflagellar transport-associated protein

  • protein C11orf74

IFTAP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
IFTAP Q86VG3 BTF3 Homo sapiens P20290
Anti Bait CoIP
18433331
Intra
IFTAP Q86VG3 BTF3 Homo sapiens P20290
Y2H
18433331
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cranioectodermal Dysplasia 1

  • Sensenbrenner Syndrome

  • CED1

  • Levin Syndrome I

  • Cranio-Ectodermal Dysplasia

  • Dysplasia, Cranioectodermal, Type 1

  • Cranioectodermal Dysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06611 IFTAP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus IFTAP VGNC VGNC:52633
Felis catus IFTAP VGNC VGNC:81987
Mus musculus IFTAP MGD MGI:1915420
Canis familiaris IFTAP VGNC VGNC:51850
Macaca mulatta IFTAP VGNC VGNC:70379
Rattus norvegicus IFTAP RGD RGD:1309730
Others IFTAP NCBI