BTF3 - basic transcription factor 3 Gene

Also Known as NACB; BTF3a; BTF3b; BETA-NAC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 689

About BTF3

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:73,498,442-73,505,667 (from NCBI)

This gene has 14 transcripts (splice variants), 169 orthologues and 3 paralogues. Ubiquitous expression in ovary (RPKM 354.7), bone marrow (RPKM 186.5) and 25 other tissues.

Summary

This gene encodes the basic transcription factor 3. This protein forms a stable complex with RNA polymerase IIB and is required for transcriptional initiation. Alternative splicing results in multiple transcript variants encoding different isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]

BTF3 Products (4)

mRNA Protein Name
NM_001037637.2 NP_001032726.1 transcription factor BTF3 isoform A
NM_001207.5 NP_001198.2 transcription factor BTF3 isoform B
NM_001393652.1 NP_001380581.1 transcription factor BTF3 isoform C
NM_001393653.1 NP_001380582.1 transcription factor BTF3 isoform D

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18025262 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of protein localization to endoplasmic reticulum IDA
IDA: Inferred from direct assay
10982809 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
10982809 GOA
part of nascent polypeptide-associated complex IPI
IPI: Inferred from physical interaction
20214399 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTF3 Protein Structure

NAC

NAC: NAC domain (85 - 141)

  • 0
  • 100
  • 206 a.a.
Protein Preferred Names Protein Names

transcription factor BTF3

  • NAC-beta

BTF3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BTF3 P20290 TXLNA Homo sapiens P40222
Validated Y2H
25416956
Intra
BTF3 P20290 TXLNA Homo sapiens P40222
Y2H Array
25416956
Intra
BTF3 P20290 TXLNA Homo sapiens P40222
Anti Tag CoIP
33961781
Intra
BTF3 P20290 TXLNB Homo sapiens Q8N3L3
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

BTF3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82560 BTF3 Antibody (YA2305) WB, IHC-P, IP Human, Mouse, Rat
HY-P82560A BTF3 Antibody (YA2305)(PBS only) WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 14

  • Primary Ciliary Dyskinesia 14

  • CILD14

  • Primary Ciliary Dyskinesia 14 With Or Without Situs Inversus

  • Ciliary Dyskinesia, Primary, 14, With Or Without Situs Inversus

  • Ics14

  • Immotile Cilia Syndrome 14

  • Dyskinesia, Ciliary, Primary, Type 14
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164144 EPZ033294 Inhibitor 98.41% Unkown
HY-RS01660 BTF3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01661 BTF3L4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01675 BTN3A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19120 Btf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25610 Btf3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BTF3 MGD MGI:1202875
Rattus norvegicus BTF3 RGD RGD:1308095
Canis familiaris BTF3 VGNC VGNC:52111
Bos taurus BTF3 VGNC VGNC:26595
Felis catus BTF3 VGNC VGNC:102168
Others BTF3 NCBI