Blk - B lymphoid kinase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12143

Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; negative regulation of leukocyte proliferation; and regulation of leukocyte apoptotic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in cytosol. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including 2-cell stage embryo; central nervous system; ileum; male reproductive gland or organ; and peripheral nervous system. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 11 and systemic lupus erythematosus. Orthologous to human Blk (Blk proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Blk Products (1)

mRNA Protein Name
NM_007549.2 NP_031575.2 tyrosine-protein kinase Blk

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8636124 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase Blk

  • b lymphocyte kinase

  • p55-Blk

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-157442 GLPG3312 Inhibitor 98.63% Phase 1

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-118105 RK-20448 Inhibitor 99.38% Unkown
HY-120622 BMS-243117 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Blk NCBI NCBI:640