BLK - BLK proto-oncogene, Src family tyrosine kinase Gene

Also Known as MODY11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 640

About BLK

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:11,494,387-11,564,599 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues, 32 paralogues and is associated with 3 phenotypes. Biased expression in lymph node (RPKM 18.9), spleen (RPKM 13.7) and 4 other tissues.

Summary

This gene encodes a nonreceptor tyrosine-kinase of the Src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates Insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

BLK Products (2)

mRNA	Protein	Name
NM_001330465.2	NP_001317394.1	tyrosine-protein kinase Blk isoform 2
NM_001715.3	NP_001706.2	tyrosine-protein kinase Blk isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables non-membrane spanning protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	876631	GOA
enables non-membrane spanning protein tyrosine kinase activity	IMP IMP: Inferred from mutant phenotype	23555801	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16273093	GOA
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	30356214	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in B cell receptor signaling pathway	IDA IDA: Inferred from direct assay	876631	GOA
involved in B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23555801	GOA
involved in peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	30356214	GOA
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	19667185	GOA
involved in positive regulation of protein binding	IMP IMP: Inferred from mutant phenotype	23555801	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BLK Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
505 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase Blk	B lymphoid tyrosine kinase

BLK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BLK	P51451	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	BLK	P51451	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	BLK	P51451	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	BLK	P51451	ZBTB32	Homo sapiens	A0A0C4DGF1	Y2H Prey Pooling	32296183
Intra	BLK	P51451	ZBTB32	Homo sapiens	A0A0C4DGF1	Y2H Array	32296183
Intra	BLK	P51451	ZNF774	Homo sapiens	Q6NX45	Y2H Array	32296183
Intra	BLK	P51451	ZNF774	Homo sapiens	Q6NX45	Validated Y2H	32296183
Intra	BLK	P51451	ZNF774	Homo sapiens	Q6NX45	Y2H Prey Pooling	32296183
Intra	BLK	P51451	FXR1	Homo sapiens	P51114-2	Y2H Prey Pooling	32296183
Intra	BLK	P51451	EFS	Homo sapiens	O43281-2	Y2H Prey Pooling	32296183
Intra	BLK	P51451	EFS	Homo sapiens	O43281-2	Y2H Array	32296183
Intra	BLK	P51451	FLACC1	Homo sapiens	Q96Q35-2	Validated Y2H	32296183
Intra	BLK	P51451	FLACC1	Homo sapiens	Q96Q35-2	Y2H Prey Pooling	32296183
Intra	BLK	P51451	FLACC1	Homo sapiens	Q96Q35-2	Y2H Array	32296183
Intra	BLK	P51451	PXN	Homo sapiens	P49023-2	Y2H Prey Pooling	32296183
Intra	BLK	P51451	PXN	Homo sapiens	P49023-2	Y2H Array	32296183
Intra	BLK	P51451	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	BLK	P51451	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	BLK	P51451	GRB10	Homo sapiens	Q13322-4	Y2H Array	32296183
Intra	BLK	P51451	GRB10	Homo sapiens	Q13322-4	Validated Y2H	32296183
Intra	BLK	P51451	GRB10	Homo sapiens	Q13322-4	Y2H Prey Pooling	32296183
Intra	BLK	P51451	KIT	Homo sapiens	P10721	FPS	24728074
Intra	BLK	P51451	STAP2	Homo sapiens	Q9UGK3	Validated Y2H	32296183
Intra	BLK	P51451	STAP2	Homo sapiens	Q9UGK3	Y2H Array	32296183
Intra	BLK	P51451	STAP2	Homo sapiens	Q9UGK3	Y2H Prey Pooling	32296183
Intra	BLK	P51451	SLA	Homo sapiens	Q13239-3	Y2H Prey Pooling	32296183
Intra	BLK	P51451	SLA	Homo sapiens	Q13239-3	Validated Y2H	32296183
Intra	BLK	P51451	SLA	Homo sapiens	Q13239-3	Y2H Array	32296183
Intra	BLK	P51451	JAKMIP1	Homo sapiens	Q96N16	Validated Y2H	32296183
Intra	BLK	P51451	JAKMIP1	Homo sapiens	Q96N16	Y2H Array	32296183
Intra	BLK	P51451	JAKMIP1	Homo sapiens	Q96N16	Y2H Prey Pooling	32296183
Intra	BLK	P51451	TDP2	Homo sapiens	O95551	Y2H Prey Pooling	32296183
Intra	BLK	P51451	TDP2	Homo sapiens	O95551	Y2H Array	32296183
Intra	BLK	P51451	SSBP3	Homo sapiens	Q9BWW4	Validated Y2H	32296183
Intra	BLK	P51451	SSBP3	Homo sapiens	Q9BWW4	Y2H Array	32296183
Intra	BLK	P51451	SSBP3	Homo sapiens	Q9BWW4	Y2H Prey Pooling	32296183
Intra	BLK	P51451	EGFR	Homo sapiens	P00533	Ub Reconstruction	24658140
Intra	BLK	P51451	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Intra	BLK	P51451	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	31980649
Intra	BLK	P51451	VIM	Homo sapiens	P08670	Anti Tag CoIP	31980649
Intra	BLK	P51451	SH2D1B	Homo sapiens	O14796	Y2H Prey Pooling	32296183
Intra	BLK	P51451	SH2D1B	Homo sapiens	O14796	Y2H Array	32296183
Intra	BLK	P51451	BIRC2	Homo sapiens	Q13490	Y2H Prey Pooling	32296183
Intra	BLK	P51451	BIRC2	Homo sapiens	Q13490	Validated Y2H	32296183
Intra	BLK	P51451	BIRC2	Homo sapiens	Q13490	Y2H Array	32296183
Intra	BLK	P51451	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	BLK	P51451	STAT3	Homo sapiens	P40763	Y2H Array	25416956
Intra	BLK	P51451	STAT3	Homo sapiens	P40763	Y2H Array	32296183
Intra	BLK	P51451	STAT3	Homo sapiens	P40763	Y2H Prey Pooling	25416956
Intra	BLK	P51451	STAT3	Homo sapiens	P40763	Y2H Prey Pooling	32296183
Intra	BLK	P51451	STAT3	Homo sapiens	P40763	Y2H Array	31515488
Intra	BLK	P51451	AR	Homo sapiens	P10275	FPS	24728074
Intra	BLK	P51451	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	BLK	P51451	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	BLK	P51451	EFS	Homo sapiens	O43281	Y2H Prey Pooling	25416956
Intra	BLK	P51451	EFS	Homo sapiens	O43281	Y2H Array	31515488
Intra	BLK	P51451	EFS	Homo sapiens	O43281	Validated Y2H	25416956
Intra	BLK	P51451	FXR2	Homo sapiens	P51116	Y2H Array	32296183
Intra	BLK	P51451	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	32296183
Intra	BLK	P51451	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	BLK	P51451	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	BLK	P51451	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	BLK	P51451	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	BLK	P51451	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	BLK	P51451	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	BLK	P51451	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	BLK	P51451	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	BLK	P51451	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	BLK	P51451	PIK3R3	Homo sapiens	Q92569	Y2H Array	32296183
Intra	BLK	P51451	PIK3R3	Homo sapiens	Q92569	Y2H Prey Pooling	32296183
Intra	BLK	P51451	PIK3R3	Homo sapiens	Q92569	Validated Y2H	32296183
Intra	BLK	P51451	PIK3R1	Homo sapiens	P27986-2	Y2H Array	32296183
Intra	BLK	P51451	PIK3R1	Homo sapiens	P27986-2	Y2H Prey Pooling	32296183
Intra	BLK	P51451	CRKL	Homo sapiens	P46109	Y2H Array	32296183
Intra	BLK	P51451	CRKL	Homo sapiens	P46109	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BLK Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72853	BLK Protein, Human (sf9, GST)	P51451 (M1-P505)	≥ 85%, as determined by reducing SDS-PAGE.

BLK Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85056	BLK Antibody (YA4748)	IHC-P, ELISA	Human

Related Diseases

Diseases	Alias
Maturity-Onset Diabetes Of The Young, Type 11	Maturity-Onset Diabetes Of The Young Type 11 MODY11 Maturity-Onset Diabetes Of The Young 11 Mody-11 Mody Type 11 Diabetes Of The Young, Maturity-Onset, Type 11
Systemic Lupus Erythematosus	Lupus Nephritis SLE Disseminated Lupus Erythematosus Systemic Lupus Erythematosus, Susceptibility To Lupus Erythematosus, Systemic Lupus Nephritis, Susceptibility To Libman-Sacks Disease Systemic Lupus Erythematosus Susceptibility To Sle - Lupus Erythematosus, Systemic Le Syndrome Lupus Lupus Erythematosus Systemic Lupus Erythematosus, Systemic, Susceptibility To Lupus Vulgaris Lupus Erythematosus, Discoid Lupus Erythematosus Systemic Lupus Erythematosus Nos Sle - [Systemic Lupus Erythematosus]
Maturity-Onset Diabetes Of The Young	MODY Maturity Onset Diabetes Mellitus In Young Mason-Type Diabetes Mason Type Diabetes Maturity Onset Diabetes Of The Young Mody Syndrome Diabetes Of The Young, Maturity-Onset
Maturity-Onset Diabetes Of The Young, Type 7	Maturity-Onset Diabetes Of The Young Type 7 MODY7 Maturity-Onset Diabetes Of The Young, Type Vii Maturity-Onset Diabetes Of The Young 7 Mody-7 Mody Type 7 Diabetes Of The Young, Maturity-Onset, Type 7
Maturity-Onset Diabetes Of The Young, Type 9	Maturity-Onset Diabetes Of The Young Type 9 MODY9 Maturity-Onset Diabetes Of The Young, Type Ix Maturity-Onset Diabetes Of The Young 9 Mody-9 Mody Type 9 Diabetes Of The Young, Maturity-Onset, Type 9
Maturity-Onset Diabetes Of The Young, Type 13	Maturity-Onset Diabetes Of The Young Type 13 MODY13 Mody Type 13 Mody, Type 13 Maturity-Onset Diabetes Of The Young 13 Diabetes Of The Young, Maturity-Onset, Type 13
Maturity-Onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction	Maturity-Onset Diabetes Of The Young Type 8 MODY8 Dped Maturity-Onset Diabetes Of The Young, Type Viii Mody Type 8 Diabetes And Pancreatic Exocrine Dysfunction Diabetes-Pancreatic Exocrine Dysfunction Syndrome Diabetes And Pancreatic Exocrine Maturity-Onset Diabetes Of The Young Type 8 With Exocrine Dysfunction Maturity-Onset Diabetes Of The Young 8 With Exocrine Dysfunction Diabetes And Pancreatic Exocrine Dysfunction Syndrome Mody-8 Diabetes Of The Young, Maturity-Onset, Type 8
Maturity-Onset Diabetes Of The Young, Type 14	Maturity-Onset Diabetes Of The Young Type 14 MODY14 Maturity-Onset Diabetes Of The Young 14 Diabetes Of The Young, Maturity-Onset, Type 14
Kawasaki Disease	Mucocutaneous Lymph Node Syndrome Acute Febrile Mucocutaneous Lymph Node Syndrome Kawasaki Syndrome Kd Infantile Polyarteritis Kawasaki Disease, Susceptibility To Acute Febrile Mcls Kawasaki'S Disease Mlns KWD
Maturity-Onset Diabetes Of The Young, Type 10	Maturity-Onset Diabetes Of The Young Type 10 MODY10 Maturity-Onset Diabetes Of The Young 10 Mody-10 Mody Type 10 Diabetes Of The Young, Maturity-Onset, Type 10
Keratolytic Winter Erythema	KWE Oudtshoorn Skin Disease Erythrokeratolysis Hiemalis Ichthyosis Erythrokeratolysis Hiemalis Oudtshoorn Skin Oudtshoorn Disease
Maturity-Onset Diabetes Of The Young, Type 6	MODY6 Maturity-Onset Diabetes Of The Young Type 6 Maturity-Onset Diabetes Of The Young 6 Mody Type 6 Mody, Type 6 Mody-6 Diabetes Of The Young, Maturity-Onset, Type 6
Rheumatoid Arthritis	RA Arthritis, Rheumatoid Rheumatoid Arthritis, Susceptibility To Arthritis Or Polyarthritis, Rheumatic Atrophic Arthritis Rheumatism Arthritis Rheumatoid Polyarthritis
Heart Aneurysm	Cardiac Aneurysm
Coronary Aneurysm	Aneurysm Of Coronary Vessels Aneurysmal Lesion Of Coronary Artery Arteriovenous Aneurysm Of Coronary Vessels
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Maturity-Onset Diabetes Of The Young, Type 4	Maturity-Onset Diabetes Of The Young Type 4 MODY4 Mody, Type Iv Mody Type 4 Mody, Type 4 Maturity-Onset Diabetes Of The Young 4 Mody-4 Diabetes Of The Young, Maturity-Onset, Type 4 Maturity-Onset Diabetes Of The Young, Type Iv
Maturity-Onset Diabetes Of The Young, Type 1	Maturity-Onset Diabetes Of The Young Type 1 MODY1 Mild Juvenile Diabetes Mellitus Mody, Type I Diabetes Mellitus Type 2 Mody Type 1 Mody, Type 1 Maturity-Onset Diabetes Of The Young 1 Mody-1 Diabetes Of The Young, Maturity-Onset, Type 1
Maturity-Onset Diabetes Of The Young, Type 2	Maturity-Onset Diabetes Of The Young Type 2 MODY2 Mody Glucokinase-Related Mody Type 2 Mody, Type 2 Mody, Glucokinase-Related Mody, Type Ii Maturity-Onset Diabetes Of The Young 2 Mody-2 Diabetes Of The Young, Maturity-Onset, Type 2 Diabetes Mellitus Autosomal Dominant Type Ii
Co-Trimoxazole Allergy	Bactrim Allergy Cotrimoxazol Allergy Tmp/Smx Allergy Trimethoprim/Sulfamethoxazole Allergy
Maturity-Onset Diabetes Of The Young, Type 3	Maturity-Onset Diabetes Of The Young Type 3 MODY3 Mody, Type Iii Mody Type 3 Mody, Type 3 Maturity-Onset Diabetes Of The Young 3 Mody-3 Diabetes Of The Young, Maturity-Onset, Type 3
Renal Cysts And Diabetes Syndrome	RCAD Mody5 Congenital Anomalies Of The Kidney And Urinary Tract With Diabetes Cakut With Diabetes Maturity-Onset Diabetes Of The Young Type 5 Tubulointerstitial Kidney Disease, Autosomal Dominant, 3 Adtkd3 Atypical Familial Juvenile Hyperuricemic Nephropathy Atypical Fjhn Familial Hypoplastic Glomerulocystic Kidney Maturity-Onset Diabetes Of The Young, Type 5 Hyperuricemic Nephropathy, Familial Juvenile, Atypical Fjhn, Atypical Glomerulocystic Kidney Disease, Hypoplastic Type Glomerulocystic Kidney, Familial Hypoplastic Hypoplastic Type Glomerulocystic Kidney Disease Glomerulocystic Kidney Disease Hypoplastic Type Renal-Diabetes Mody5 Syndrome
Common Variable Immunodeficiency	Cvid Common Variable Agammaglobulinemia Common Variable Immune Deficiency Acquired Hypogammaglobulinemia Hypogamma-Globulinemia, Acquired Idiopathic Immunoglobulin Deficiency Primary Antibody Deficiency Primary Hypogammaglobulinemia Acquired Agammaglobulinemia Sporadic Hypogammaglobulinemia Common Variable Hypogamma-Globulinemia Immunoglobulin Deficiency, Late-Onset Common Variable Hypogammaglobulinemia Immunodeficiency, Common Variable
Lymph Node Disease	Abnormality Of The Lymph Nodes Disorder Of Lymph Node
Permanent Neonatal Diabetes Mellitus	Pndm Permanent Diabetes Mellitus Of Infancy Pdmi Neonatal Diabetes Mellitus, Permanent
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS
Thrombocytopenia	Low Platelet Count Low Platelets Decreased Platelets Platelet Dysfunction Nos
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-157442	GLPG3312	Inhibitor	98.63%	Phase 1

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-118105	RK-20448	Inhibitor	99.38%	Unkown
HY-120622	BMS-243117	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BLK	RGD	RGD:1308859
Macaca mulatta	BLK	VGNC	VGNC:70253
Canis familiaris	BLK	VGNC	VGNC:38464
Bos taurus	BLK	VGNC	VGNC:26504
Mus musculus	BLK	MGD	MGI:88169
Felis catus	BLK	VGNC	VGNC:60121
Others	BLK	NCBI