Cacnb4 - calcium channel, voltage-dependent, beta 4 subunit Gene

Also Known as lh; Cchb4; 3110038O15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12298

Summary

Enables voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in regulation of synaptic vesicle exocytosis. Acts upstream of or within several processes, including adult walking behavior; cellular response to leukemia inhibitory factor; and hematopoietic or lymphoid organ development. Located in glutamatergic synapse. Part of voltage-gated Calcium Channel complex. Is expressed in cerebellum; heart; and telencephalon. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; episodic ataxia; episodic ataxia type 5; and idiopathic generalized epilepsy 9. Orthologous to human CACNB4 (calcium voltage-gated channel auxiliary subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]

Cacnb4 Products (6)

mRNA Protein Name
NM_001037099.3 NP_001032176.1 voltage-dependent L-type calcium channel subunit beta-4 isoform a
NM_001285426.2 NP_001272355.1 voltage-dependent L-type calcium channel subunit beta-4 isoform c
NM_001285427.2 NP_001272356.1 voltage-dependent L-type calcium channel subunit beta-4 isoform d
NM_001285428.1 NP_001272357.1 voltage-dependent L-type calcium channel subunit beta-4 isoform e
NM_001355059.2 NP_001341988.1 voltage-dependent L-type calcium channel subunit beta-4 isoform f
NM_146123.4 NP_666235.1 voltage-dependent L-type calcium channel subunit beta-4 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10328888 MGI
enables voltage-gated calcium channel activity IMP
IMP: Inferred from mutant phenotype
9705268 MGI
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IDA
IDA: Inferred from direct assay
10322048 MGI
enables voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IMP
IMP: Inferred from mutant phenotype
10322048 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Peyer's patch development IMP
IMP: Inferred from mutant phenotype
5037658 MGI
NOT acts upstream of or within T cell differentiation IMP
IMP: Inferred from mutant phenotype
17028169 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17028169 MGI
acts upstream of or within adult walking behavior IMP
IMP: Inferred from mutant phenotype
7562514 MGI
acts upstream of or within cAMP metabolic process IMP
IMP: Inferred from mutant phenotype
7595494 MGI
acts upstream of or within calcium ion transport IMP
IMP: Inferred from mutant phenotype
7595494 MGI
acts upstream of or within cellular response to leukemia inhibitory factor IEP
IEP: Inferred from expression pattern
20439489 MGI
acts upstream of or within detection of light stimulus involved in visual perception IMP
IMP: Inferred from mutant phenotype
16636205 MGI
acts upstream of or within gamma-aminobutyric acid secretion IMP
IMP: Inferred from mutant phenotype
7595494 MGI
acts upstream of or within gamma-aminobutyric acid signaling pathway IMP
IMP: Inferred from mutant phenotype
7472490 MGI
acts upstream of or within muscle cell development IMP
IMP: Inferred from mutant phenotype
17320843 MGI
acts upstream of or within nervous system process IMP
IMP: Inferred from mutant phenotype
1321503 MGI
acts upstream of or within neuromuscular junction development IMP
IMP: Inferred from mutant phenotype
17320843 MGI
acts upstream of or within neuronal action potential propagation IMP
IMP: Inferred from mutant phenotype
7261997 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
12151514 MGI
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
10322048 MGI
involved in regulation of synaptic vesicle exocytosis IMP
IMP: Inferred from mutant phenotype
10322048 MGI
acts upstream of or within spleen development IMP
IMP: Inferred from mutant phenotype
5037658 MGI
NOT acts upstream of or within synaptic transmission, GABAergic IMP
IMP: Inferred from mutant phenotype
10322048 MGI
acts upstream of or within synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
10322048 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
5037658 MGI
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10322048 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
10322048 MGI
part of voltage-gated calcium channel complex IDA
IDA: Inferred from direct assay
10328888 MGI
part of voltage-gated calcium channel complex IMP
IMP: Inferred from mutant phenotype
9705268 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

voltage-dependent L-type calcium channel subunit beta-4

  • CAB4

  • calcium channel voltage-dependent subunit beta 4

Cacnb4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Cacnb4 Q8R0S4 ERC1 Homo sapiens Q8IUD2-2
Anti Tag CoIP
22107844
Intra
Cacnb4 Q8R0S4 Ppp2r5d Mus musculus Q91V89
Anti Bait CoIP
22892567
Intra
Cacnb4 Q8R0S4 Ppp2r5d Mus musculus Q91V89
Anti Tag CoIP
22892567
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149662 TMDJ-035 Inhibitor 99.92% Unkown
HY-RS01808 CACNB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cacnb4 NCBI NCBI:785