Ctnnd1 - catenin (cadherin associated protein), delta 1 Gene

Also Known as P120; Catns; Ctnnd; mKIAA0384

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12388

Summary

Enables protein domain specific binding activity and protein Phosphatase binding activity. Acts upstream of or within several processes, including glomerulus morphogenesis; positive regulation of cellular protein metabolic process; and salivary gland development. Located in several cellular components, including adherens junction; apicolateral plasma membrane; and bicellular tight junction. Part of flotillin complex. Is expressed in several structures, including 4-8 cell stage embryo; alimentary system; central nervous system; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in blepharocheilodontic syndrome 2. Orthologous to human CTNND1 (catenin delta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ctnnd1 Products (9)

mRNA	Protein	Name
NM_001085448.1	NP_001078917.1	catenin delta-1 isoform 2
NM_001085449.1	NP_001078918.1	catenin delta-1 isoform 3
NM_001085450.1	NP_001078919.1	catenin delta-1 isoform 1
NM_001085453.2	NP_001078922.1	catenin delta-1 isoform 4
NM_001355064.1	NP_001341993.1	catenin delta-1 isoform 1
NM_001355065.1	NP_001341994.1	catenin delta-1 isoform 2
NM_001355066.1	NP_001341995.1	catenin delta-1 isoform 5
NM_001355067.1	NP_001341996.1	catenin delta-1 isoform 6
NM_007615.4	NP_031641.2	catenin delta-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9670943	MGI
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	18794329	MGI
enables protein phosphatase binding	IPI IPI: Inferred from physical interaction	16973135	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cell adhesion	IMP IMP: Inferred from mutant phenotype	14657280	MGI
acts upstream of or within cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	16399075	MGI
acts upstream of or within epithelial cell differentiation involved in salivary gland development	IMP IMP: Inferred from mutant phenotype	16399075	MGI
acts upstream of or within glomerulus morphogenesis	IMP IMP: Inferred from mutant phenotype	21521738	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	21521738	MGI
acts upstream of or within morphogenesis of a polarized epithelium	IMP IMP: Inferred from mutant phenotype	16399075	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine autophosphorylation	IGI IGI: Inferred from genetic interaction	17344476	MGI
acts upstream of or within positive regulation of protein processing	IGI IGI: Inferred from genetic interaction	17344476	MGI
acts upstream of or within positive regulation of protein processing	IMP IMP: Inferred from mutant phenotype	17344476	MGI
acts upstream of or within salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	16399075	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	15775979	MGI
located in apicolateral plasma membrane	IDA IDA: Inferred from direct assay	26404741	MGI
located in bicellular tight junction	IDA IDA: Inferred from direct assay	17130295	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	23990464	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	17344476	MGI
part of flotillin complex	IDA IDA: Inferred from direct assay	24046456	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	14657280	MGI
located in membrane	IDA IDA: Inferred from direct assay	14657280	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17344476	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	17344476	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
catenin delta-1	CAS cadherin-associated Src substrate catenin src p120 catenin p120(cas) p120(ctn)

Ctnnd1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Ctnnd1	P30999	Zbtb33	Mus musculus	Q8BN78	Y2H	10207085
Intra	Ctnnd1	P30999	Cttn	Mus musculus	Q60598	Pull Down	17576929
Intra	Ctnnd1	P30999	Cttn	Mus musculus	Q60598	Anti Bait CoIP	17576929
Intra	Ctnnd1	P30999	Cttn	Mus musculus	Q60598	Anti Tag CoIP	17576929

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03311	CTNND1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctnnd1	NCBI	NCBI:1500