Cldn2 - claudin 2 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12738

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene display normal appearance, activity, growth and behavior, but are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. The proteins encoded by this gene and another family member Cldn12 are also critical for vitamin D-dependent Ca2+ absorption between enterocytes. [provided by RefSeq, Aug 2010]

Cldn2 Products (2)

mRNA Protein Name
NM_001410421.1 NP_001397350.1 claudin-2
NM_016675.5 NP_057884.1 claudin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
10562289 MGI
enables paracellular tight junction channel activity IDA
IDA: Inferred from direct assay
12432083 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10562289 MGI
Biological Process GO Annotation Evidence References Source
involved in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
IDA: Inferred from direct assay
10508613 MGI
involved in cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
32149733 MGI
involved in innate immune response in mucosa IMP
IMP: Inferred from mutant phenotype
28618266 MGI
involved in paracellular transport IDA
IDA: Inferred from direct assay
12432083 MGI
involved in paracellular transport IMP
IMP: Inferred from mutant phenotype
20727355 MGI
involved in regulation of bile acid secretion IMP
IMP: Inferred from mutant phenotype
25068494 MGI
involved in regulation of intestinal D-glucose absorption IMP
IMP: Inferred from mutant phenotype
23089202 MGI
involved in regulation of intestinal lipid absorption IMP
IMP: Inferred from mutant phenotype
23089202 MGI
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
9647647 MGI
located in bicellular tight junction IMP
IMP: Inferred from mutant phenotype
32149733 MGI
located in tight junction IDA
IDA: Inferred from direct assay
12432083 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

claudin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2468 Xylobiose Inhibitor 98.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cldn2 NCBI NCBI:9075