Cldn2 - claudin 2 Gene

Mus musculus

Gene ID: 12738 | Gene type: protein coding

About Cldn2

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The knockout mice lacking this gene display normal appearance, activity, growth and behavior, but are defective in the leaky and cation-selective paracellular permeability properties of renal proximal tubules. The proteins encoded by this gene and another family member Cldn12 are also critical for vitamin D-dependent Ca2+ absorption between enterocytes. [provided by RefSeq, Aug 2010]

Cldn2 Products(2)

mRNA	Protein	Name
NM_001410421.1	NP_001397350.1	claudin-2
NM_016675.5	NP_057884.1	claudin-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	10562289	MGI
enables paracellular tight junction channel activity	IDA IDA: Inferred from direct assay	12432083	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10562289	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules	IDA IDA: Inferred from direct assay	10508613	MGI
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	32149733	MGI
involved in innate immune response in mucosa	IMP IMP: Inferred from mutant phenotype	28618266	MGI
involved in paracellular transport	IDA IDA: Inferred from direct assay	12432083	MGI
involved in paracellular transport	IMP IMP: Inferred from mutant phenotype	20727355	MGI
involved in regulation of bile acid secretion	IMP IMP: Inferred from mutant phenotype	25068494	MGI
involved in regulation of intestinal D-glucose absorption	IMP IMP: Inferred from mutant phenotype	23089202	MGI
involved in regulation of intestinal lipid absorption	IMP IMP: Inferred from mutant phenotype	23089202	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	9647647	MGI
located in bicellular tight junction	IMP IMP: Inferred from mutant phenotype	32149733	MGI
located in tight junction	IDA IDA: Inferred from direct assay	12432083	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

claudin-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2468	Xylobiose	Inhibitor	98.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cldn2	NCBI	NCBI:9075

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