Col18a1 - collagen, type XVIII, alpha 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12822

Summary

Predicted to enable identical protein binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within several processes, including angiogenesis; endothelial cell morphogenesis; and positive regulation of endothelial cell apoptotic process. Located in basement membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary angle-closure glaucoma. Orthologous to human COL18A1 (Collagen type XVIII alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col18a1 Products (8)

mRNA Protein Name
NM_001109991.2 NP_001103461.1 collagen alpha-1(XVIII) chain isoform 1 precursor
NM_001406250.1 NP_001393179.1 collagen alpha-1(XVIII) chain isoform 3 precursor
NM_001406251.1 NP_001393180.1 collagen alpha-1(XVIII) chain isoform 4 precursor
NM_001406252.1 NP_001393181.1 collagen alpha-1(XVIII) chain isoform 5
NM_001406253.1 NP_001393182.1 collagen alpha-1(XVIII) chain isoform 5
NM_001406254.1 NP_001393183.1 collagen alpha-1(XVIII) chain isoform 5
NM_001406255.1 NP_001393184.1 collagen alpha-1(XVIII) chain isoform 6
NM_009929.4 NP_034059.2 collagen alpha-1(XVIII) chain isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17324935 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within angiogenesis IDA
IDA: Inferred from direct assay
15188432 MGI
acts upstream of or within angiogenesis IMP
IMP: Inferred from mutant phenotype
11927538 MGI
acts upstream of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
15188432 MGI
acts upstream of endothelial cell apoptotic process IDA
IDA: Inferred from direct assay
15188432 MGI
acts upstream of or within endothelial cell morphogenesis IDA
IDA: Inferred from direct assay
15188432 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
15254016 MGI
acts upstream of or within positive regulation of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
15188432 MGI
acts upstream of or within positive regulation of endothelial cell apoptotic process IDA
IDA: Inferred from direct assay
15188432 MGI
acts upstream of or within positive regulation of vascular endothelial cell proliferation IDA
IDA: Inferred from direct assay
15188432 MGI
acts upstream of vascular endothelial cell proliferation IDA
IDA: Inferred from direct assay
15188432 MGI
Cellular Component GO Annotation Evidence References Source
located in basement membrane IDA
IDA: Inferred from direct assay
7568013 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-1(XVIII) chain

  • alpha-1(XVIII) collagen

  • endostatin

  • procollagen, type XVIII, alpha 1

Recombinant Col18a1 Proteins

Cat. No. Product Name Accession Purity
HY-P70347 Collagen alpha-1(XVIII) chain/COL18A1 Protein, Mouse (HEK293, His) P39061 (H1591-K1774) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02968 COL18A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18436 Col18a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24918 Col18a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col18a1 NCBI NCBI:80781