Crx - cone-rod homeobox Gene

Also Known as Crx1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12951

Summary

Enables several functions, including DNA-binding transcription factor activity; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and nuclear receptor binding activity. Involved in regulation of transcription, DNA-templated. Acts upstream of or within positive regulation of transcription by RNA polymerase II and retina development in camera-type eye. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including eye; face; and nervous system. Used to study Leber congenital amaurosis 7. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 7 and cone-rod dystrophy 2. Orthologous to human CRX (cone-rod homeobox). [provided by Alliance of Genome Resources, Apr 2022]

Crx Products (2)

mRNA Protein Name
NM_001113330.1 NP_001106801.1 cone-rod homeobox protein isoform 2
NM_007770.4 NP_031796.1 cone-rod homeobox protein isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
15689355 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20026326 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
14613968 MGI
enables nuclear receptor binding IPI
IPI: Inferred from physical interaction
16574740 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14613968 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12407160 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
12407160 MGI
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16574740 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: Inferred from mutant phenotype
21052544 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
15689355 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
15689355 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cone-rod homeobox protein

  • cone-rod homeobox containing

Crx Antibodies

Cat. No. Product Name Application Reactivity
HY-P86825 CRX Antibody (YA6518) WB, IHC-P Mouse, Rat

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-111792 GSK1795091 Agonist 94.48% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153759 CRX000227 Modulator 95.0% Unkown
HY-155801 CRX 527 / Unkown
HY-RS03203 CRX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118984 CRX-526 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crx NCBI NCBI:1406