REG3G - regenerating family member 3 gamma Gene

Also Known as PAP1B; PAPIB; PAP IB; PAP-1B; UNQ429; LPPM429; REG III; REG-III

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 130120

About REG3G

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:79,025,702-79,028,501 (from NCBI)

This gene has 5 transcripts (splice variants), 788 orthologues and 5 paralogues. Restricted expression toward testis (RPKM 33.7).

Summary

This gene encodes a member of the regenerating islet-derived genes (REG)3 protein family. These proteins are secreted, C-type lectins with a carbohydrate recognition domain and N-terminal signal peptide. The protein encoded by this gene is an antimicrobial lectin with activity against Gram-positive bacteria. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Nov 2014]

REG3G Products (3)

mRNA Protein Name
NM_001008387.3 NP_001008388.1 regenerating islet-derived protein 3-gamma isoform 1 preproprotein
NM_001270040.2 NP_001256969.1 regenerating islet-derived protein 3-gamma isoform 2 preproprotein
NM_198448.4 NP_940850.1 regenerating islet-derived protein 3-gamma isoform 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables oligosaccharide binding IDA
IDA: Inferred from direct assay
16931762 GOA
enables peptidoglycan binding IDA
IDA: Inferred from direct assay
16931762 GOA
Biological Process GO Annotation Evidence References Source
involved in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
IDA: Inferred from direct assay
16931762 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REG3G Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (58 - 172)

  • 0
  • 100
  • 175 a.a.
Protein Preferred Names Protein Names

regenerating islet-derived protein 3-gamma

  • REG-3-gamma

Recombinant REG3G Proteins

Cat. No. Product Name Accession Purity
HY-P71255 REG-3 gamma/REG3G Protein, Human (HEK293, Fc) Q6UW15-1 (E27-D175) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71256 REG-3 gamma/REG3G Protein, Human (HEK293, His) Q6UW15-1 (E27-D175) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Chemical Colitis
Pancreatitis

  • Mumps Pancreatitis
Alzheimer Disease 12

  • Ad12

  • Alzheimer'S Disease 12

  • Alzheimer Disease, Familial, 12

  • Alzheimer Disease Familial 12
X-Linked Immunodeficiency 74

  • Immunodeficiency 74, Covid-19-Related, X-Linked

  • Imd74

  • Respiratory Insufficiency Due To Sars-Cov-2 Viral Infection

  • Tlr7 Deficiency

  • X-Linked Immunodeficiency 74,Covid-19-Related
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11821 REG3G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19737 Reg3g Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26233 Reg3g Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus REG3G MGD MGI:109406
Macaca mulatta REG3G VGNC VGNC:106208
Rattus norvegicus REG3G RGD RGD:3256
Others REG3G NCBI