Cyp1a2 - cytochrome P450, family 1, subfamily a, polypeptide 2 Gene

Also Known as CP12; CYPIA2; P450-3

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13077

Summary

Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Acts upstream of or within several processes, including cellular response to cadmium ion; dibenzo-p-dioxin metabolic process; and hydrogen peroxide biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in liver. Human ortholog(s) of this gene implicated in breast cancer; chronic obstructive pulmonary disease; endometrial cancer; and porphyria cutanea tarda. Orthologous to human CYP1A2 (Cytochrome P450 family 1 subfamily A member 2). [provided by Alliance of Genome Resources, Apr 2022]

Cyp1a2 Products (1)

mRNA	Protein	Name
NM_009993.3	NP_034123.1	cytochrome P450 1A2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA IDA: Inferred from direct assay	8274012	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cellular respiration	IMP IMP: Inferred from mutant phenotype	7761462	MGI
acts upstream of or within cellular response to cadmium ion	IDA IDA: Inferred from direct assay	16183037	MGI
acts upstream of or within dibenzo-p-dioxin metabolic process	IMP IMP: Inferred from mutant phenotype	9240455	MGI
acts upstream of or within hydrogen peroxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	14980704	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	7761462	MGI
acts upstream of or within porphyrin-containing compound metabolic process	IMP IMP: Inferred from mutant phenotype	9461503	MGI
acts upstream of or within post-embryonic development	IMP IMP: Inferred from mutant phenotype	7761462	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	12438513	MGI
acts upstream of or within toxin metabolic process	IMP IMP: Inferred from mutant phenotype	17166882	MGI
acts upstream of or within xenobiotic metabolic process	IMP IMP: Inferred from mutant phenotype	8643688	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cytochrome P450 1A2	cholesterol 25-hydroxylase cytochrome P450 family 1 subfamily a polypeptide 1 cytochrome P450, 1a2, aromatic compound inducible cytochrome P450-P2 cytochrome P450-P3 hydroperoxy icosatetraenoate dehydratase

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132845	Utreloxastat	Inhibitor	99.32%	Phase 2
HY-19397	BMS-223131	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120717	VU6001966	Inhibitor	99.89%	Unkown
HY-170846	FGFRs-IN-1	Inhibitor	/	Unkown
HY-174417	NNRT-IN-10	Inhibitor	/	Unkown
HY-167632	meso-Zeaxanthin	Inhibitor	93.09%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyp1a2	NCBI	NCBI:1544