2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. 7-Benzyloxy-4-(trifluoromethyl)coumarin

7-Benzyloxy-4-(trifluoromethyl)coumarin  (Synonyms: 7-BFC)

Art. -Nr.: HY-W267897 Reinheit: 99.47%
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7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies.

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7-Benzyloxy-4-(trifluoromethyl)coumarin

7-Benzyloxy-4-(trifluoromethyl)coumarin Chemische Struktur

CAS. Nr. : 220001-53-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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7-Benzyloxy-4-(trifluoromethyl)coumarin Related Antibodies

Top Publications Citing Use of Products

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Beschreibung

7-Benzyloxy-4-(trifluoromethyl)coumarin (7-BFC) is a coumarin fluorescent substrate. 7-Benzyloxy-4-(trifluoromethyl)coumarin is a substrate for cDNA-expressed CYP1A2 and CYP3A4 and is metabolized to 7-hydroxy-4-trifluoromethylcoumarin (HFC). 7-Benzyloxy-4-(trifluoromethyl)coumarin is used for rapid CYP isoform metabolism and inhibition screening studies[1].

Molekulargewicht

320.26

Formel

C17H11F3O3
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

C1=CC=C(C=C1)COC2=CC3=C(C=C2)C(=CC(=O)O3)C(F)(F)F
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 125 mg/mL (390.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1225 mL 15.6123 mL 31.2246 mL
5 mM 0.6245 mL 3.1225 mL 6.2449 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1225 mL 15.6123 mL 31.2246 mL 78.0616 mL
5 mM 0.6245 mL 3.1225 mL 6.2449 mL 15.6123 mL
10 mM 0.3122 mL 1.5612 mL 3.1225 mL 7.8062 mL
15 mM 0.2082 mL 1.0408 mL 2.0816 mL 5.2041 mL
20 mM 0.1561 mL 0.7806 mL 1.5612 mL 3.9031 mL
25 mM 0.1249 mL 0.6245 mL 1.2490 mL 3.1225 mL
30 mM 0.1041 mL 0.5204 mL 1.0408 mL 2.6021 mL
40 mM 0.0781 mL 0.3903 mL 0.7806 mL 1.9515 mL
50 mM 0.0624 mL 0.3122 mL 0.6245 mL 1.5612 mL
60 mM 0.0520 mL 0.2602 mL 0.5204 mL 1.3010 mL
80 mM 0.0390 mL 0.1952 mL 0.3903 mL 0.9758 mL
100 mM 0.0312 mL 0.1561 mL 0.3122 mL 0.7806 mL
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7-Benzyloxy-4-(trifluoromethyl)coumarin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

7-Benzyloxy-4-(trifluoromethyl)coumarin220001-53-67-BFCCytochrome P450CYPsCoumarinsubstratecDNACYP1A2CYP3A47-hydroxy-4-trifluoromethylcoumarinHFCCYPmetabolisminhibition screeningInhibitorinhibitorinhibit

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