Dach1 - dachshund family transcription factor 1 Gene

Also Known as Dac; Dach

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13134

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in regulation of nuclear cell cycle DNA replication. Acts upstream of or within several processes, including negative regulation of cell population proliferation; respiratory gaseous exchange by respiratory system; and suckling behavior. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; limb; and sensory organ. Orthologous to human DACH1 (dachshund family transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Dach1 Products (2)

mRNA Protein Name
NM_001038610.2 NP_001033699.1 dachshund homolog 1 isoform 2
NM_007826.3 NP_031852.1 dachshund homolog 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14628042 MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
20869363 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11025202 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within development of primary female sexual characteristics IGI
IGI: Inferred from genetic interaction
18395837 MGI
acts upstream of or within epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
20869363 MGI
acts upstream of or within negative regulation of cell proliferation involved in contact inhibition IGI
IGI: Inferred from genetic interaction
17182846 MGI
acts upstream of or within negative regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
17182846 MGI
acts upstream of or within negative regulation of fibroblast proliferation IGI
IGI: Inferred from genetic interaction
17182846 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17182846 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
17182846 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20869363 MGI
acts upstream of or within regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
14628042 MGI
acts upstream of or within regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
14628042 MGI
involved in regulation of nuclear cell cycle DNA replication IMP
IMP: Inferred from mutant phenotype
16980615 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: Inferred from mutant phenotype
11238885 MGI
acts upstream of or within suckling behavior IMP
IMP: Inferred from mutant phenotype
11238885 MGI
acts upstream of or within type B pancreatic cell proliferation IMP
IMP: Inferred from mutant phenotype
20869363 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11025202 MGI
located in nucleus IDA
IDA: Inferred from direct assay
11025202 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
14628042 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
17182846 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dachshund homolog 1

  • dachshund 1

Dach1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Dach1 Q9QYB2 Ncor1 Mus musculus Q60974
Pull Down
12130660
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03513 DACH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dach1 NCBI NCBI:1602