Dach1 - dachshund family transcription factor 1 Gene

Mus musculus

Also known as Dac; Dach

Gene ID: 13134 | Gene type: protein coding

About Dach1

Summary

Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in regulation of nuclear cell cycle DNA replication. Acts upstream of or within several processes, including negative regulation of cell population proliferation; respiratory gaseous exchange by respiratory system; and suckling behavior. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; limb; and sensory organ. Orthologous to human DACH1 (dachshund family transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Dach1 Products(2)

mRNA	Protein	Name
NM_001038610.2	NP_001033699.1	dachshund homolog 1 isoform 2
NM_007826.3	NP_031852.1	dachshund homolog 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14628042	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20869363	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11025202	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within development of primary female sexual characteristics	IGI IGI: Inferred from genetic interaction	18395837	MGI
acts upstream of or within epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	20869363	MGI
acts upstream of or within negative regulation of cell proliferation involved in contact inhibition	IGI IGI: Inferred from genetic interaction	17182846	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	17182846	MGI
acts upstream of or within negative regulation of fibroblast proliferation	IGI IGI: Inferred from genetic interaction	17182846	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17182846	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17182846	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20869363	MGI
acts upstream of or within regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14628042	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	14628042	MGI
involved in regulation of nuclear cell cycle DNA replication	IMP IMP: Inferred from mutant phenotype	16980615	MGI
acts upstream of or within respiratory gaseous exchange by respiratory system	IMP IMP: Inferred from mutant phenotype	11238885	MGI
acts upstream of or within suckling behavior	IMP IMP: Inferred from mutant phenotype	11238885	MGI
acts upstream of or within type B pancreatic cell proliferation	IMP IMP: Inferred from mutant phenotype	20869363	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11025202	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11025202	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	14628042	MGI
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	17182846	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

dachshund homolog 1

dachshund 1

Dach1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Dach1	Q9QYB2	Ncor1	Mus musculus	Q60974	Pull Down	12130660

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03513	DACH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dach1	NCBI	NCBI:1602

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