Dazl - deleted in azoospermia-like Gene

Also Known as Dazh; Tpx2; Dazl1; Dazla; Tpx-2; Daz-like

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13164

Summary

This gene encodes a member of the depleted in azoospermia-like (DAZL) protein family. Members of this family contain an RNA recognition motif, interact with poly A binding proteins, and may be involved in the initiation of translation. The encoded protein is expressed in the cytoplasm of pluripotent stem cells, and in both male and female germ cells, where it is essential for gametogenesis. Disruption of this gene is associated with infertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

Dazl Products (2)

mRNA	Protein	Name
NM_001277863.2	NP_001264792.1	deleted in azoospermia-like isoform 2
NM_010021.6	NP_034151.3	deleted in azoospermia-like isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	10903443	MGI
enables mRNA 3'-UTR binding	IDA IDA: Inferred from direct assay	11804965	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	16001084	MGI
enables translation activator activity	IDA IDA: Inferred from direct assay	16001084	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within female meiosis II	IMP IMP: Inferred from mutant phenotype	21460039	MGI
acts upstream of or within germ cell development	IMP IMP: Inferred from mutant phenotype	9288969	MGI
acts upstream of or within oocyte maturation	IMP IMP: Inferred from mutant phenotype	21460039	MGI
acts upstream of or within positive regulation of meiotic nuclear division	IMP IMP: Inferred from mutant phenotype	14611631	MGI
involved in positive regulation of translational initiation	IDA IDA: Inferred from direct assay	16001084	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	9288969	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15081113	MGI
located in ribosome	IDA IDA: Inferred from direct assay	11604102	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
deleted in azoospermia-like	DAZ-like autosomal deleted in azoospermia-like 1

Dazl Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Dazl	Q64368	Dazl	Mus musculus	Q64368	Pull Down	10903443
Intra	Dazl	Q64368	Dctn1	Mus musculus	O08788	Anti Bait CoIP	16946704
Intra	Dazl	Q64368	Dynll1	Mus musculus	P63168	Pull Down	16946704
Intra	Dazl	Q64368	Dynll1	Mus musculus	P63168	Imaging	16946704
Intra	Dazl	Q64368	Dazl	Mus musculus	Q64368	Y2H	10903443
Intra	Dazl	Q64368	Dync1i1	Mus musculus	O88485	Anti Bait CoIP	16946704
Intra	Dazl	Q64368	Dync1i1	Mus musculus	O88485	Anti Tag CoIP	16946704
Intra	Dazl	Q64368	SRSF3	Homo sapiens	P84103	Y2H	10823932
Intra	Dazl	Q64368	Dync1i1	Mus musculus	O88485	Pull Down	16946704
Intra	Dazl	Q64368	Dynll1	Mus musculus	P63168	Anti Tag CoIP	16946704

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03542	DAZL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dazl	NCBI	NCBI:1618