Ackr1 - atypical chemokine receptor 1 (Duffy blood group) Gene

Also Known as FY; Dfy; GPD; Darc; CCBP1; CD234; ESTM35

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13349

Summary

Predicted to enable C-C chemokine binding activity. Acts upstream of or within inflammatory response and regulation of chemokine production. Predicted to be located in endosome and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; lung; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Plasmodium vivax malaria and malaria. Orthologous to human ACKR1 (atypical Chemokine Receptor 1 (Duffy blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Ackr1 Products (1)

mRNA	Protein	Name
NM_010045.3	NP_034175.2	atypical chemokine receptor 1

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within inflammatory response	IMP IMP: Inferred from mutant phenotype	10961863	MGI
acts upstream of or within regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	20643340	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
atypical chemokine receptor 1	Duffy antigen receptor for chemokines Duffy blood group, chemokine receptor duffy antigen/chemokine receptor glycoprotein D

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00160	ACKR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18799	Ackr1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25288	Ackr1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ackr1	NCBI	NCBI:2532