ACKR1 - atypical chemokine receptor 1 (Duffy blood group) Gene

Also Known as FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1; DARC/ACKR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2532

About ACKR1

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,204,875-159,206,500 (from NCBI)

This gene has 4 transcripts (splice variants), 105 orthologues and is associated with 3 phenotypes. Broad expression in fat (RPKM 23.4), urinary bladder (RPKM 20.5) and 22 other tissues.

Summary

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ACKR1 Products (2)

mRNA Protein Name
NM_001122951.3 NP_001116423.1 atypical chemokine receptor 1 isoform a
NM_002036.4 NP_002027.2 atypical chemokine receptor 1 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables C-C chemokine binding IPI
IPI: Inferred from physical interaction
7517217 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18230715 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

atypical chemokine receptor 1

  • Duffy antigen chemokine receptor

Recombinant ACKR1 Proteins

Cat. No. Product Name Accession Purity
HY-P700380 ACKR1 Protein, Human (Cell-Free, His) Q16570-1 (M1-S336) ≥ 85%, as determined by reducing SDS-PAGE.

ACKR1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81909 DARC Antibody (YA1654) WB, IHC-P, ICC/IF, IP, FC Human, Mouse

Related Diseases

Diseases Alias
White Blood Cell Count Quantitative Trait Locus 1

  • WBCQ1
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Genital Herpes

  • Herpes Genitalis

  • Genital Herpes Simplex

  • Venereal Herpes

  • Virus-Genital Herpes
Plasmodium Vivax Malaria

  • Malaria, Vivax

  • Malaria By Plasmodium Vivax

  • Vivax Malaria

  • Malaria Vivax
Herpes Simplex

  • Herpes Simplex Infections

  • Herpesvirus Hominis Disease

  • Herpes Simplex Disease

  • Herpesviral Infection Due To Herpes Simplex

  • Infections Due To Simplex Virus

  • Herpes Nos
Vitreous Abscess
Mixed Malaria

  • Malaria By More Than One Parasite

  • Malaria Fever By More Than One Parasite
Drug Dependence
Laryngotracheitis
Herpetic Whitlow

  • Herpetic Felon
Herpes Simplex Virus Keratitis

  • Dendritic Keratitis

  • Keratitis, Dendritic

  • Keratitis, Herpetic
Neutropenia

  • Leukopenia
Parasitic Protozoa Infectious Disease

  • Protozoan Infections

  • Mastigophora Infectious Disease

  • Sarcomastigophora Infectious Disease
Glaucomatocyclitic Crisis

  • Posner-Schlossman Syndrome

  • Terrien-Viel Syndrome
Balanoposthitis

  • Balanitis Due To Infection
Viral Infectious Disease

  • Viral Disease

  • Arbovirus Infections

  • Virus Infection

  • Virus Diseases

  • Viral Infection

  • Viral Infections

  • Virus Infections
Hereditary Elliptocytosis

  • Congenital Elliptocytosis

  • Ovalocytosis

  • Elliptocytosis, Hereditary

  • He

  • Elliptocytosis Hereditary

  • Congenital Ovalocytosis

  • Elliptocytosis

  • Hereditary Elliptocytosis With Infantile Poikilocytosis

  • Hereditary Ovalocytosis

  • Oval Erythrocytosis

  • He - [Hereditary Elliptocytosis]

  • Elliptocytosis Anaemia
Glucosephosphate Dehydrogenase Deficiency

  • G6pd Deficiency

  • Glucose-6-Phosphate Dehydrogenase Deficiency

  • Deficiency Of Glucose-6-Phosphate Dehydrogenase

  • Glucose 6 Phosphate Dehydrogenase Deficiency

  • Deficiency Of G-6pd

  • G6pdd
Sickle Cell Anemia

  • Hemoglobin Sc Disease

  • Anemia, Sickle Cell

  • Hbsc Disease

  • Sickle Cell-Hemoglobin C Disease Syndrome

  • Hb Ss Disease

  • Sickle Cell Trait

  • Drepanocytosis

  • Haemoglobin Sc Disease

  • Hb Sc Disease

  • Hb-S/Hb-C Disease

  • Hb-Ss Disease Without Crisis

  • Hemoglobin S Disease Without Crisis

  • Sickle Cell Anaemia

  • Sickle-Cell/Hb-C Disease Without Crisis

  • Sickle Cell - Hemoglobin C Disease

  • Hbs Disease

  • Hemoglobin S Disease

  • Sickling Disorder Due To Hemoglobin S

  • SKCA

  • Sickle Cell Disease

  • Sickle Cell-Hemoglobin C Disease

  • Sickle-Cell Disease Carrier

  • Sickle-Cell Heterozygous Disorder

  • Haemoglobin A-S Genotype

  • Hb-S - [Sickle Cell Haemoglobin] Carrier

  • Sickle Cell Haemoglobin Trait

  • As - [Sickle Cell Trait]

  • Hbas - [Sickle Cell Haemoglobin Trait]

  • Sickle-Cell Trait Haemoglobin Disease

  • Haemoglobin Sickle Cell Trait Disorder

  • Heterozygous Sickle Cell Trait

  • Hbas - [Heterozygous Haemoglobin S]
Charcot-Marie-Tooth Disease

  • Cmt

  • Hmsn

  • Hereditary Motor And Sensory Neuropathy

  • Pma

  • Cmt - Charcot-Marie-Tooth Disease

  • Charcot Marie Tooth Disease

  • Charcot-Marie-Tooth Hereditary Neuropathy

  • Charcot-Marie-Tooth Syndrome

  • Peroneal Muscular Atrophy

  • Hereditary Motor And Sensory Neuropathies
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00160 ACKR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18799 Ackr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25288 Ackr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ACKR1 MGD MGI:1097689
Canis familiaris ACKR1 VGNC VGNC:53112
Felis catus ACKR1 VGNC VGNC:107839
Bos taurus ACKR1 VGNC VGNC:58436
Rattus norvegicus ACKR1 RGD RGD:1596198
Macaca mulatta ACKR1 VGNC VGNC:99834
Others ACKR1 NCBI