COX7C - cytochrome c oxidase subunit 7C Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1350

About COX7C

Cytogenetic location: 5q14.3 Genomic coordinates (GRCh38): 5:86,617,941-86,620,962 (from NCBI)

This gene has 7 transcripts (splice variants) and 306 orthologues. Ubiquitous expression in kidney (RPKM 507.5), heart (RPKM 430.4) and 25 other tissues.

Summary

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13. [provided by RefSeq, Jul 2008]

COX7C Products (1)

mRNA Protein Name
NM_001867.3 NP_001858.1 cytochrome c oxidase subunit 7C, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
31536960 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial membrane IDA
IDA: Inferred from direct assay
30030519 GOA
part of respiratory chain complex IV IDA
IDA: Inferred from direct assay
31536960 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COX7C Protein Structure

COX7C

COX7C: Cytochrome c oxidase subunit VIIc (1 - 63)

  • 0
  • 63 a.a.
Protein Preferred Names Protein Names

cytochrome c oxidase subunit 7C, mitochondrial

  • cytochrome c oxidase polypeptide VIIc

COX7C Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
COX7C P15954 MAGEA2 Homo sapiens P43356
Y2H Prey Pooling
32296183
Intra
COX7C P15954 MAGEA2 Homo sapiens P43356
Validated Y2H
32296183
Intra
COX7C P15954 MAGEA2 Homo sapiens P43356
Y2H Array
32296183
Intra
COX7C P15954 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
COX7C P15954 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
COX7C P15954 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Mitochondrial Complex Iv Deficiency, Nuclear Type 1

  • Cytochrome C Oxidase Deficiency

  • Mitochondrial Complex Iv Deficiency

  • Cox Deficiency

  • Cytochrome-C Oxidase Deficiency Disease

  • MC1DN4

  • Cytochrome-C Oxidase Deficiency

  • MC4DN1

  • Mitochondrial Complex I Deficiency, Nuclear Type 4

  • Complex 4 Mitochondrial Respiratory Chain Deficiency

  • Complex Iv Deficiency

  • Mitochondrial Complex 1 Deficiency, Nuclear Type 4

  • Nuclear Type Mitochondrial Complex I Deficiency 4

  • Deficiency Of Mitochondrial Respiratory Chain Complex4

  • MT-C4D

  • Complex Iv Mitochondrial Respiratory Chain Deficiency

  • Lethal Neonatal Cardiomyopathy Hypertrophic Due To Cytochrome C Oxidase Deficiency

  • Mitochondrial Complex Iv Deficiency, Nuclear, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03077 COX7C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22452 Cox7c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28975 Cox7c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus COX7C RGD RGD:2300145
Mus musculus COX7C MGD MGI:103226
Macaca mulatta COX7C VGNC VGNC:110473
Others COX7C NCBI