Lefty1 - left right determination factor 1 Gene

Also Known as Ebaf; Leftb; Stra3; Tgfb4; lefty; lefty-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13590

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which plays a role in left-right asymmetry determination of organ systems during development. Mice lacking a functional copy of this gene exhibit embryonic lethality and defects in left-right patterning. [provided by RefSeq, Aug 2016]

Lefty1 Products (1)

mRNA Protein Name
NM_010094.4 NP_034224.1 left-right determination factor 1 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nodal binding IPI
IPI: Inferred from physical interaction
15062104 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior axis specification IGI
IGI: Inferred from genetic interaction
15004567 MGI
acts upstream of or within cell migration involved in gastrulation IGI
IGI: Inferred from genetic interaction
15004567 MGI
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
15004567 MGI
involved in determination of left/right symmetry IDA
IDA: Inferred from direct assay
9708732 MGI
involved in heart morphogenesis IMP
IMP: Inferred from mutant phenotype
9708732 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
15004567 MGI
involved in negative regulation of nodal receptor complex assembly IDA
IDA: Inferred from direct assay
15062104 MGI
involved in negative regulation of nodal signaling pathway IDA
IDA: Inferred from direct assay
15062104 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9708732 MGI
acts upstream of or within response to retinoic acid IDA
IDA: Inferred from direct assay
10500184 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
15062104 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

left-right determination factor 1

  • TGF-beta-4

  • left-right determination, factor B

  • protein lefty-1

  • stimulated by retinoic acid gene 3 protein

  • transforming growth factor beta-4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-10321G PD173074 (GMP) Inhibitor / Unkown
HY-RS07585 LEFTY1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lefty1 NCBI NCBI:10637