Efna1 - ephrin A1 Gene

Also Known as B61; Efl1; Epl1; Eplg1; Lerk1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13636

Summary

Enables Ephrin Receptor binding activity. Involved in several processes, including heart valve morphogenesis; negative regulation of dendritic spine morphogenesis; and regulation of blood vessel endothelial cell migration. Acts upstream of or within several processes, including Ephrin Receptor signaling pathway; nervous system development; and regulation of MAPK cascade. Is anchored component of plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human EFNA1 (ephrin A1). [provided by Alliance of Genome Resources, Apr 2022]

Efna1 Products (2)

mRNA Protein Name
NM_001162425.1 NP_001155897.1 ephrin-A1 isoform 2
NM_010107.4 NP_034237.3 ephrin-A1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
22568954 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
22036564 MGI
Biological Process GO Annotation Evidence References Source
involved in aortic valve morphogenesis IMP
IMP: Inferred from mutant phenotype
20960543 MGI
involved in endocardial cushion to mesenchymal transition involved in heart valve formation IMP
IMP: Inferred from mutant phenotype
20960543 MGI
acts upstream of or within ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
14988728 MGI
involved in ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
17143272 MGI
involved in mitral valve morphogenesis IMP
IMP: Inferred from mutant phenotype
20960543 MGI
acts upstream of or within negative regulation of MAPK cascade IDA
IDA: Inferred from direct assay
16547242 MGI
involved in negative regulation of dendritic spine morphogenesis IDA
IDA: Inferred from direct assay
17143272 MGI
involved in negative regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
20960543 MGI
acts upstream of or within negative regulation of thymocyte apoptotic process IDA
IDA: Inferred from direct assay
16547242 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
20960543 MGI
acts upstream of or within neuron differentiation IDA
IDA: Inferred from direct assay
15145949 MGI
acts upstream of or within notochord formation IGI
IGI: Inferred from genetic interaction
11287184 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15145949 MGI
involved in regulation of angiogenesis IDA
IDA: Inferred from direct assay
16782872 MGI
acts upstream of or within regulation of axonogenesis IDA
IDA: Inferred from direct assay
14988728 MGI
involved in regulation of blood vessel endothelial cell migration IDA
IDA: Inferred from direct assay
16782872 MGI
involved in regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
17143272 MGI
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
18794797 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin-A1

  • EPH-related receptor tyrosine kinase ligand 1

  • immediate early response protein B61

Recombinant Efna1 Proteins

Cat. No. Product Name Accession Purity
HY-P70373 Ephrin-A1/EFNA1 Protein, Mouse (HEK293, Fc-His) P52793 (D19-S182) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73024 Ephrin-A1/EFNA1 Protein, Mouse (HEK293, His) P52793 (D19-S182) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P75234 Ephrin-A1/EFNA1 Protein, Mouse (HEK293, Fc) P52793 (D19-S182) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04192 EFNA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17656 Efna1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24117 Efna1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Efna1 NCBI NCBI:1942