En1 - engrailed 1 Gene

Also Known as En-1; Mo-en.1; engrailed-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 13798

Summary

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; drinking behavior; and motor learning. Acts upstream of or within several processes, including embryonic forelimb morphogenesis; nervous system development; and regionalization. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb; and limb primordium. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

En1 Products (1)

mRNA Protein Name
NM_010133.3 NP_034263.2 homeobox protein engrailed-1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
23863478 MGI
Biological Process GO Annotation Evidence Références Source
involved in adult locomotory behavior IMP
IMP: Inferred from mutant phenotype
17267560 MGI
involved in cerebellum development IGI
IGI: Inferred from genetic interaction
8848044 MGI
acts upstream of or within dopaminergic neuron differentiation IGI
IGI: Inferred from genetic interaction
15175251 MGI
acts upstream of or within dorsal/ventral pattern formation IMP
IMP: Inferred from mutant phenotype
8684466 MGI
involved in drinking behavior IMP
IMP: Inferred from mutant phenotype
17267560 MGI
involved in embryonic brain development IMP
IMP: Inferred from mutant phenotype
7624797 MGI
acts upstream of or within embryonic forelimb morphogenesis IGI
IGI: Inferred from genetic interaction
9362463 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: Inferred from genetic interaction
15242796 MGI
acts upstream of or within embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
8684466 MGI
involved in embryonic limb morphogenesis IMP
IMP: Inferred from mutant phenotype
7624797 MGI
acts upstream of or within hindbrain development IGI
IGI: Inferred from genetic interaction
15607945 MGI
acts upstream of or within limb development IMP
IMP: Inferred from mutant phenotype
23863478 MGI
acts upstream of or within midbrain development IGI
IGI: Inferred from genetic interaction
15175251 MGI
involved in midbrain development IGI
IGI: Inferred from genetic interaction
8848044 MGI
acts upstream of or within midbrain-hindbrain boundary development IMP
IMP: Inferred from mutant phenotype
15607945 MGI
involved in motor learning IMP
IMP: Inferred from mutant phenotype
17267560 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
23863478 MGI
involved in negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
15175251 MGI
acts upstream of or within neuron development IGI
IGI: Inferred from genetic interaction
11312297 MGI
acts upstream of or within neuron development IMP
IMP: Inferred from mutant phenotype
23863478 MGI
acts upstream of or within neuron differentiation IGI
IGI: Inferred from genetic interaction
15340832 MGI
acts upstream of or within pigmentation IMP
IMP: Inferred from mutant phenotype
9362463 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9102311 MGI
acts upstream of or within proximal/distal pattern formation IMP
IMP: Inferred from mutant phenotype
8684466 MGI
acts upstream of or within regulation of gene expression IGI
IGI: Inferred from genetic interaction
23863478 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
23863478 MGI
involved in social behavior IMP
IMP: Inferred from mutant phenotype
17267560 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homeobox protein engrailed-1

  • homeobox protein en-1

  • mo-En-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (68)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-139298 L319 99.83% Unkown
HY-W010639 4-Penten-1-ol 99.99% Unkown
HY-W102301 (E)-tert-Butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl)oxy)silane 97.0% Unkown
HY-46575 (R)-2-(But-3-en-1-yl)oxirane Control / Unkown
HY-W000981 1-Cyclopentenylboronic acid ≥97.0% Unkown
HY-34409 3-Methyl-2-butenal 97.30% Unkown
HY-43064 (E)-4,4,4-Trifluorobut-2-en-1-ol 98.23% Unkown
HY-43405 (E)-1,3-Di(thiophen-2-yl)prop-2-en-1-one 99.44% Unkown
HY-W015515 L-Citronellol Inhibitor 99.92% Unkown
HY-W015936 (E)-Hex-2-en-1-ol 99.98% Unkown
HY-W038588 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-2-en-1-one / Unkown
HY-165707 3-(((Z)-Octadec-9-en-1-yl)oxy)propane-1,2-diyl dioleate 99% Unkown
HY-W016976 Allyl heptanoate 99.80% Unkown
HY-RS17866 En1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W026038 (Z)-Non-2-en-1-ol 98.00% Unkown
HY-W034462 tert-Butyl (4-aminobut-2-en-1-yl)carbamate hydrochloride 97.0% Unkown
HY-W784556 5'-DMTr-dU(Allylamine-CO-F3)-3'-CE-phosphoramidite 98.0% Unkown
HY-139456S 1-(4-Aza-8-hydroxy-6-oxo)oct-2-en-1-oylimidazole-d3 / Unkown
HY-CE00800A 3-(4-Methylpent-3-en-1-yl)pent-2-enedioyl-CoA / Unkown
HY-CE00868 3-Hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA / Unkown
HY-CE01438 6-{(1S,5S)-4-Oxo-5-[(2Z)-pent-2-en-1-yl]cyclopent-2-en-1-yl}hexanoyl-CoA / Unkown
HY-E71488 2-Chloro-4-carboxymethylenebut-2-en-1,4-olide isomerase / Unkown
HY-E71534 2-Glutathionyl-2-methylbut-3-en-1-ol dehydrogenase / Unkown
HY-E71824 4-Hydroxy-3-methylbut-2-en-1-yl diphosphate reductase / Unkown
HY-E71993 7,8-Dihydroxykynurenate 8,8a-dioxygenase / Unkown
HY-N12135 15α-Hydroxy-20-oxo-6,7-seco-ent-kaur-16-en-1,7α(6,11α)-diolide / Unkown
HY-N17152 4-Hydroxy-4-methylcyclohex-2-en-1-one / Unkown
HY-N17161 (E)-5-Hydroxy-6-isoprenyl-2-(pent-1-en-1-yl)benzofuran-4-carbaldehyde / Unkown
HY-N17408 (E)-2-(2-Hydroxy-4-methylpheny1)-prop-l-en-1-yl acetate / Unkown
HY-N1873 (E)-4-(3,4-Dimethoxyphenyl)but-3-en-1-ol 90% Unkown
HY-N2296 (2R,3R)-3,7-Dihydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methylbut-2-en-1-yl)chroman-4-one / Unkown
HY-RS04365 EN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W010639S 4-Penten-ol-d9 / Unkown
HY-W017558 (Z)-Non-6-en-1-ol 99.58% Unkown
HY-W075520 N,1-di(pyridin-4-yl)methanimine 99.72% Unkown
HY-W127449 trans-2-Nonen-1-ol / Unkown
HY-W243917 4-[[2,3,4,4,6-Pentakis(4-carboxyphenoxy)-1,3,5-triaza-2,4λ5,6-triphosphacyclohex-4-en-1-yl]oxy]benzoicacid / Unkown
HY-W283271 3-Methylcyclohex-2-en-1-ol 98.00% Unkown
HY-W397173 3-Hydroxy-1,3-di(pyridin-4-yl)prop-2-en-1-one / Unkown
HY-W456395 (Z)-4-(Cyclooct-4-en-1-yloxy)-4-oxobutanoic acid / Unkown
HY-W856110 3-(4-Carboxybenzyl)-2-(2-(3-(2-(3-(4-carboxybenzyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)ethylidene)-2-chlorocyclohex-1-en-1-yl)vinyl)-1,1-dimethyl-1H-benzo[e]indol-3-ium bromide / Unkown
HY-Y0400S 2-Bromoethylammonium-d4 bromide / Unkown
HY-Z2289S1 (S)-Ibrutinib-d4 / Unkown
HY-152065S 3,7-Dimethyloct-6-en-1-ol-d2 / Unkown
HY-165708 7(E)-Nonadecenol / Unkown
HY-165708A (Z)-Nonadec-7-en-1-ol / Unkown
HY-165728 (Z)-Octadec-9-en-1-yl methylglycinate / Unkown
HY-165841 11(E)-Octadecenol / Unkown
HY-165883 15(Z)-Tetracosenol / Unkown
HY-165894 Myristoleyl behenate / Unkown
HY-166005 Myristoleyl laurate / Unkown
HY-166006 Myristoleyl myristate / Unkown
HY-403667 2-Cyanoethyl pent-4-en-1-yl diisopropylphosphoramidite / Unkown
HY-N12898 (Z)-Tetradec-7-en-1-ol Activator / Unkown
HY-N9018 4-(6-Methyl-4-oxohept-5-en-2-yl)cyclohex-2-en-1-one / Unkown
HY-RS24335 En1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W007259R (2-Methylprop-1-en-1-yl)benzene (Standard) / Unkown
HY-W008836S (E)-Hex-3-en-1-ol-d2 / Unkown
HY-W108416 (Z)-Tetradec-11-en-1-ol 98.0% Unkown
HY-W142921S Allyl methyl disulfide-d3 / Unkown
HY-W190911 Cyclooct-4-en-1-yl(2-(2-(2-hydroxyethoxy)ethoxy)ethyl)carbamate / Unkown
HY-W249951 Ethyl 2-(4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-en-1-yl)acetate / Unkown
HY-W319939 3-(4-Hydroxy-3-methoxyphenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one Modulator / Unkown
HY-W654395 Methyl jasmonate-d5 (mixture of diastereomers) / Unkown
HY-W784553 Amino-modifier-C6-dC CEP / Unkown
HY-W784554 5'-DMTr-Amino-modifier-C6-dT-3'-CE-phosphoramidite / Unkown
HY-W838865 11-Dodecenol 98.0% Unkown
HY-W923632 (Z)-Tetradec-9-en-1-ol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens En1 NCBI NCBI:2019