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Epha7 - Eph receptor A7 Gene

Also Known as Ebk; Ehk3; Mdk1; Cek11; Hek11

Species: Mus musculus

Gene Type: protein coding

Gene ID: 13841

Summary

Enables chemorepellent activity; growth factor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including Ephrin Receptor signaling pathway; negative regulation of nervous system development; and regulation of protein phosphorylation. Acts upstream of or within nephric duct morphogenesis; nervous system development; and positive regulation of neuron apoptotic process. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; foot bone; genitourinary system; and sensory organ. Orthologous to human EphA7 (EPH receptor A7). [provided by Alliance of Genome Resources, Apr 2022]

Epha7 Products (3)

mRNA	Protein	Name
NM_001122889.1	NP_001116361.1	ephrin type-A receptor 7 isoform 2 precursor
NM_001290434.1	NP_001277363.1	ephrin type-A receptor 7 isoform 3 precursor
NM_010141.4	NP_034271.3	ephrin type-A receptor 7 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GPI-linked ephrin receptor activity	IDA IDA: Inferred from direct assay	11089974	MGI
enables axon guidance receptor activity	IMP IMP: Inferred from mutant phenotype	16301174	MGI
enables chemorepellent activity	IDA IDA: Inferred from direct assay	15996548	MGI
enables growth factor binding	IPI IPI: Inferred from physical interaction	22568954	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11089974	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in brain development	IMP IMP: Inferred from mutant phenotype	15902206	MGI
acts upstream of or within branching morphogenesis of a nerve	IMP IMP: Inferred from mutant phenotype	15996548	MGI
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	11089974	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	24707048	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	24707048	MGI
involved in negative regulation of collateral sprouting	IDA IDA: Inferred from direct assay	19036963	MGI
involved in negative regulation of synapse assembly	IDA IDA: Inferred from direct assay	19036963	MGI
acts upstream of or within nephric duct morphogenesis	IGI IGI: Inferred from genetic interaction	25139858	MGI
acts upstream of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15902206	MGI
acts upstream of or within positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	15902206	MGI
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19036963	MGI
involved in regulation of cell-cell adhesion	IDA IDA: Inferred from direct assay	11089974	MGI
involved in regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	15902206	MGI
involved in regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	11089974	MGI
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	24707048	MGI
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	24707048	MGI
involved in regulation of protein autophosphorylation	IDA IDA: Inferred from direct assay	11089974	MGI
acts upstream of or within retinal ganglion cell axon guidance	IMP IMP: Inferred from mutant phenotype	15996548	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	24707048	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	24707048	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ephrin type-A receptor 7	EPH homology kinase 3 developmental kinase 1 embryonic brain kinase

Recombinant Epha7 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75746	EphA7 Protein, Mouse (HEK293, His)	Q61772 (Q28-I556)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04431	EPHA7 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17251	Epha7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23705	Epha7 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epha7	NCBI	NCBI:2045