EPHA7 - EPH receptor A7 Gene

Also Known as EHK3; EK11; EHK-3; HEK11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2045

About EPHA7

Cytogenetic location: 6q16.1 Genomic coordinates (GRCh38): 6:93,240,020-93,419,559 (from NCBI)

This gene has 20 transcripts (splice variants), 137 orthologues, 53 paralogues and is associated with 103 phenotypes. Broad expression in prostate (RPKM 3.4), kidney (RPKM 2.8) and 16 other tissues.

Summary

This gene belongs to the Ephrin Receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

EPHA7 Products (10)

mRNA Protein Name
NM_001288629.2 NP_001275558.1 ephrin type-A receptor 7 isoform 2 precursor
NM_001288630.2 NP_001275559.1 ephrin type-A receptor 7 isoform 3 precursor
NM_001376465.1 NP_001363394.1 ephrin type-A receptor 7 isoform 4 precursor
NM_001376466.1 NP_001363395.1 ephrin type-A receptor 7 isoform 5 precursor
NM_001376467.1 NP_001363396.1 ephrin type-A receptor 7 isoform 6 precursor
NM_001376468.1 NP_001363397.1 ephrin type-A receptor 7 isoform 7 precursor
NM_001376469.1 NP_001363398.1 ephrin type-A receptor 7 isoform 8 precursor
NM_001376470.1 NP_001363399.1 ephrin type-A receptor 7 isoform 9
NM_001376471.1 NP_001363400.1 ephrin type-A receptor 7 isoform 10
NM_004440.4 NP_004431.1 ephrin type-A receptor 7 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22036564 GOA
Biological Process GO Annotation Evidence References Source
involved in ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
17726105 GOA
involved in regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17726105 GOA
involved in regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
17726105 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
16862074 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHA7 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (32 - 205)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (269 - 308)

fn3

fn3: Fibronectin type III domain (333 - 422)

fn3

fn3: Fibronectin type III domain (452 - 527)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (557 - 630)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (633 - 889)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (923 - 985)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 998 a.a.
Protein Preferred Names Protein Names

ephrin type-A receptor 7

  • EPH homology kinase 3

EPHA7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EPHA7 Q15375 EPHB2 Homo sapiens P29323
Affinity Chrom
35384245
Intra
EPHA7 Q15375 EPHB2 Homo sapiens P29323
Anti Tag CoIP
35384245
Intra
EPHA7 Q15375 EPHA3 Homo sapiens P29320
Anti Tag CoIP
33961781
Intra
EPHA7 Q15375 EPHA3 Homo sapiens P29320
BioID
35384245
Intra
EPHA7 Q15375 EFNA5 Homo sapiens P52803
Anti Tag CoIP
33961781
Intra
EPHA7 Q15375 EFNA5 Homo sapiens P52803
Comigration in SDS
22036564
Intra
EPHA7 Q15375 CSF1R Homo sapiens P07333
Anti Tag CoIP
35384245
Intra
EPHA7 Q15375 NTRK3 Homo sapiens Q16288
Anti Tag CoIP
35384245
Intra
EPHA7 Q15375 NTRK3 Homo sapiens Q16288
Affinity Chrom
35384245
Cross
EPHA7 Q15375 Efna1 Mus musculus P52793
Anti Bait CoIP
22036564
Intra
EPHA7 Q15375 EPHA2 Homo sapiens P29317
Anti Bait CoIP
22036564
Intra
EPHA7 Q15375 EPHA2 Homo sapiens P29317
BioID
35384245
Intra
EPHA7 Q15375 EPHA2 Homo sapiens P29317
Affinity Chrom
35384245
Intra
EPHA7 Q15375 EPHA2 Homo sapiens P29317
Anti Tag CoIP
35384245
Intra
EPHA7 Q15375 EPHB4 Homo sapiens P54760
Anti Tag CoIP
35384245
Intra
EPHA7 Q15375 EPHB4 Homo sapiens P54760
BioID
35384245
Intra
EPHA7 Q15375 EPHB4 Homo sapiens P54760
Affinity Chrom
35384245
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHA7 Proteins

Cat. No. Product Name Accession Purity
HY-P70842 EphA7 Protein, Human (HEK293, His) Q15375-1 (Q28-I556) ≥ 95%, as determined by reducing SDS-PAGE.

EPHA7 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85143 EPHA7 Antibody (YA4835) WB, IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Brachydactyly-Syndactyly Syndrome

  • BDSD

  • Brachydactyly-Syndactyly-Oligodactyly Syndrome

  • Brachydactyly-Syndactyly, Zhao Type

  • BDSDO
Syndactyly, Type V

  • Syndactyly Type 5

  • SDTY5

  • Syndactyly With Metacarpal And Metatarsal Fusion

  • Syndactyly With Associated Metacarpal And Metatarsal Fusion

  • Postaxial Syndactyly With Metacarpal Synostosis

  • Sd5

  • Syndactyly 5

  • Syndactyly Type V
Brachydactyly, Type A4

  • Brachymesophalangy Ii And V

  • Temtamy Type Brachydactyly

  • Brachydactyly Type A4

  • BDA4

  • Brachymesophalangy 2 And 5

  • Brachydactyly Temtamy Type

  • Brachydactyly, Temtamy Type
Gallbladder Adenocarcinoma

  • Adenocarcinoma Of The Gallbladder

  • Carcinoma Of The Gallbladder
Maxillary Sinus Cancer

  • Malignant Neoplasm Of Antrum

  • Malignant Tumor Of The Maxillary Sinus

  • Maxillary Sinus Carcinoma

  • Cancer Of Maxillary Sinus

  • Maxillary Sinus Neoplasms
Maxillary Sinus Squamous Cell Carcinoma

  • Epidermoid Carcinoma Of The Maxillofacial Sinus
Brachydactyly
Camptodactyly-Tall Stature-Scoliosis-Hearing Loss Syndrome

  • Catshl Syndrome

  • Camptodactyly-Tall Stature-Scoliosis-Deafness Syndrome
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Chromosome 2q35 Duplication Syndrome

  • Syndactyly

  • Syndactyly Type 1

  • Sdty1

  • Zygodactyly

  • Syndactyly, Type I

  • Sd1

  • Syndactyly, Type 1, With Or Without Craniosynostosis

  • Symphalangism

  • Non-Syndromic Syndactyly

  • Symphalangy

  • Webbing Of Digits

  • Syndactyly, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04431 EPHA7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17251 Epha7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23705 Epha7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EPHA7 VGNC VGNC:72239
Mus musculus EPHA7 MGD MGI:95276
Canis familiaris EPHA7 VGNC VGNC:40409
Rattus norvegicus EPHA7 RGD RGD:70957
Felis catus EPHA7 VGNC VGNC:61905
Bos taurus EPHA7 VGNC VGNC:28537
Others EPHA7 NCBI