Nploc4 - NPL4 homolog, ubiquitin recognition factor Gene

Rattus norvegicus

Also known as Npl4

Gene ID: 140639 | Gene type: protein coding

About Nploc4

Summary

Enables ATPase binding activity; ubiquitin binding activity; and ubiquitin protein Ligase binding activity. Contributes to K48-linked polyubiquitin modification-dependent protein binding activity and K63-linked polyubiquitin modification-dependent protein binding activity. Involved in Golgi organization. Located in cytosol and nucleus. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. Orthologous to human NPLOC4 (NPL4 homolog, ubiquitin recognition factor). [provided by Alliance of Genome Resources, Apr 2022]

Nploc4 Products(1)

mRNA	Protein	Name
NM_080577.2	NP_542144.1	nuclear protein localization protein 4 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	10811609	RGD
contributes to K48-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	12847084	RGD
contributes to K63-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	12847084	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10811609	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10811609	RGD
enables ubiquitin binding	IDA IDA: Inferred from direct assay	18775313	RGD
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	18775313	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	12847084	RGD
involved in Golgi organization	IDA IDA: Inferred from direct assay	10811609	RGD
NOT involved in membrane fusion	IDA IDA: Inferred from direct assay	10811609	RGD
involved in retrograde protein transport, ER to cytosol	EXP EXP: Inferred from Experiment	12847084	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of UFD1-NPL4 complex	IDA IDA: Inferred from direct assay	10811609	RGD
part of VCP-NPL4-UFD1 AAA ATPase complex	EXP EXP: Inferred from Experiment	22232657	RGD
part of VCP-NPL4-UFD1 AAA ATPase complex	IDA IDA: Inferred from direct assay	10811609	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nuclear protein localization protein 4 homolog

homolog of yeast nuclear protein localization 4

nuclear protein localization 4 homolog

Nploc4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Nploc4	Q9ES54	Ufd1	Rattus norvegicus	Q9ES53	Far-WB	10811609
Intra	Nploc4	Q9ES54	Ufd1	Rattus norvegicus	Q9ES53	GMS	10811609
Intra	Nploc4	Q9ES54	Ufd1	Rattus norvegicus	Q9ES53	Anti Bait CoIP	10811609
Cross	Nploc4	Q9ES54	Ufd1	Mus musculus	P70362	GMS	22232657
Cross	Nploc4	Q9ES54	Ufd1	Mus musculus	P70362	3D-EM	22232657
Cross	Nploc4	Q9ES54	Ufd1	Mus musculus	P70362	GMS	17202270
Cross	Nploc4	Q9ES54	Ufd1	Mus musculus	P70362	Far-WB	10811609
Cross	Nploc4	Q9ES54	Ufd1	Mus musculus	P70362	TEM	22232657
Cross	Nploc4	Q9ES54	Ufd1	Mus musculus	P70362	Pull Down	10811609
Cross	Nploc4	Q9ES54	Ufd1	Mus musculus	P70362	TEM	17202270
Cross	Nploc4	Q9ES54	Vcp	Mus musculus	Q01853	GMS	22232657
Cross	Nploc4	Q9ES54	Vcp	Mus musculus	Q01853	TEM	22232657
Cross	Nploc4	Q9ES54	Vcp	Mus musculus	Q01853	GMS	17202270
Cross	Nploc4	Q9ES54	Vcp	Mus musculus	Q01853	TEM	17202270
Cross	Nploc4	Q9ES54	Vcp	Mus musculus	Q01853	3D-EM	22232657

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09489	NPLOC4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nploc4	NCBI	NCBI:55666

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