Ufd1 - ubiquitin recognition factor in ER associated degradation 1 Gene

Rattus norvegicus

Gene ID: 84478 | Gene type: protein coding

About Ufd1

Summary

Enables ATPase binding activity and signaling receptor binding activity. Predicted to be involved in ERAD pathway; negative regulation of RIG-I signaling pathway; and negative regulation of type I interferon production. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Orthologous to human UFD1 (ubiquitin recognition factor in ER associated degradation 1). [provided by Alliance of Genome Resources, Apr 2022]

Ufd1 Products(1)

mRNA	Protein	Name
NM_053418.2	NP_445870.1	ubiquitin recognition factor in ER-associated degradation protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	10811609	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10811609	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	10811609	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	16103111	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	12847084	RGD
involved in retrograde protein transport, ER to cytosol	EXP EXP: Inferred from Experiment	12847084	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of UFD1-NPL4 complex	IDA IDA: Inferred from direct assay	10811609	RGD
part of VCP-NPL4-UFD1 AAA ATPase complex	EXP EXP: Inferred from Experiment	22232657	RGD
part of VCP-NPL4-UFD1 AAA ATPase complex	IDA IDA: Inferred from direct assay	10811609	RGD
part of VCP-NPL4-UFD1 AAA ATPase complex	IPI IPI: Inferred from physical interaction	12847084	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ubiquitin recognition factor in ER-associated degradation protein 1

UB fusion protein 1	ubiquitin fusion degradation 1 like
ubiquitin fusion degradation protein 1 homolog

Ufd1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Ufd1	Q9ES53	Nploc4	Rattus norvegicus	Q9ES54	Anti Bait CoIP	10811609

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W111581	Copper(II) diethyldithiocarbamate	Inducer	98.5%	Unkown
HY-RS15414	UFD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ufd1	NCBI	NCBI:7353

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