Ufd1 - ubiquitin recognition factor in ER associated degradation 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84478

Summary

Enables ATPase binding activity and signaling receptor binding activity. Predicted to be involved in ERAD pathway; negative regulation of RIG-I signaling pathway; and negative regulation of type I interferon production. Part of UFD1-NPL4 complex and VCP-NPL4-UFD1 AAA ATPase complex. Human ortholog(s) of this gene implicated in DiGeorge syndrome and schizophrenia. Orthologous to human UFD1 (ubiquitin recognition factor in ER associated degradation 1). [provided by Alliance of Genome Resources, Apr 2022]

Ufd1 Products (1)

mRNA Protein Name
NM_053418.2 NP_445870.1 ubiquitin recognition factor in ER-associated degradation protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATPase binding IPI
IPI: Inferred from physical interaction
10811609 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10811609 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
10811609 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
16103111 RGD
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IDA
IDA: Inferred from direct assay
12847084 RGD
involved in retrograde protein transport, ER to cytosol EXP
EXP: Inferred from Experiment
12847084 RGD
Cellular Component GO Annotation Evidence References Source
part of UFD1-NPL4 complex IDA
IDA: Inferred from direct assay
10811609 RGD
part of VCP-NPL4-UFD1 AAA ATPase complex EXP
EXP: Inferred from Experiment
22232657 RGD
part of VCP-NPL4-UFD1 AAA ATPase complex IDA
IDA: Inferred from direct assay
10811609 RGD
part of VCP-NPL4-UFD1 AAA ATPase complex IPI
IPI: Inferred from physical interaction
12847084 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin recognition factor in ER-associated degradation protein 1

  • UB fusion protein 1

  • ubiquitin fusion degradation 1 like

  • ubiquitin fusion degradation protein 1 homolog

Ufd1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ufd1 Q9ES53 Nploc4 Rattus norvegicus Q9ES54
Anti Bait CoIP
10811609
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W111581 Copper(II) diethyldithiocarbamate Inducer 98.5% Unkown
HY-RS15414 UFD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ufd1 NCBI NCBI:7353