Trim63 - tripartite motif containing 63 Gene

Rattus norvegicus

Also known as Murf; Murf1; Rnf28

Gene ID: 140939 | Gene type: protein coding

About Trim63

Summary

Enables ubiquitin-protein transferase activity. Involved in several processes, including regulation of muscle adaptation; response to interleukin-1; and skeletal muscle atrophy. Acts upstream of or within muscle contraction. Located in contractile fiber. Used to study muscular dystrophy. Biomarker of muscular atrophy and muscular dystrophy. Orthologous to human TRIM63 (tripartite motif containing 63). [provided by Alliance of Genome Resources, Apr 2022]

Trim63 Products(1)

mRNA	Protein	Name
NM_080903.2	NP_543179.1	E3 ubiquitin-protein ligase TRIM63

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	11679633	RGD

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within muscle contraction	IDA IDA: Inferred from direct assay	15601779	RGD
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	24117217	RGD
involved in response to electrical stimulus involved in regulation of muscle adaptation	IDA IDA: Inferred from direct assay	21465538	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	11679633	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	11679633	RGD
involved in skeletal muscle atrophy	IEP IEP: Inferred from expression pattern	11679633	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in contractile muscle fiber	IDA IDA: Inferred from direct assay	15601779	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase TRIM63

MURF-1	RING-type E3 ubiquitin transferase TRIM63
muscle ring finger protein 1	muscle-specific RING finger protein 1
ring finger protein 28	tripartite motif containing 63, E3 ubiquitin protein ligase
tripartite motif protein 63	tripartite motif-cont

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15063	TRIM63 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trim63	NCBI	NCBI:84676

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