Trim63 - tripartite motif containing 63 Gene

Also Known as Murf; Murf1; Rnf28

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140939

Summary

Enables ubiquitin-protein transferase activity. Involved in several processes, including regulation of muscle adaptation; response to interleukin-1; and skeletal muscle atrophy. Acts upstream of or within muscle contraction. Located in contractile fiber. Used to study muscular dystrophy. Biomarker of muscular atrophy and muscular dystrophy. Orthologous to human TRIM63 (tripartite motif containing 63). [provided by Alliance of Genome Resources, Apr 2022]

Trim63 Products (1)

mRNA Protein Name
NM_080903.2 NP_543179.1 E3 ubiquitin-protein ligase TRIM63

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
11679633 RGD
Biological Process GO Annotation Evidence References Source
acts upstream of or within muscle contraction IDA
IDA: Inferred from direct assay
15601779 RGD
involved in negative regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
24117217 RGD
involved in response to electrical stimulus involved in regulation of muscle adaptation IDA
IDA: Inferred from direct assay
21465538 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
11679633 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
11679633 RGD
involved in skeletal muscle atrophy IEP
IEP: Inferred from expression pattern
11679633 RGD
Cellular Component GO Annotation Evidence References Source
located in contractile muscle fiber IDA
IDA: Inferred from direct assay
15601779 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase TRIM63

  • MURF-1

  • RING-type E3 ubiquitin transferase TRIM63

  • muscle ring finger protein 1

  • muscle-specific RING finger protein 1

  • ring finger protein 28

  • tripartite motif containing 63, E3 ubiquitin protein ligase

  • tripartite motif protein 63

  • tripartite motif-cont

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15063 TRIM63 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trim63 NCBI NCBI:84676