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Foxh1 - forkhead box H1 Gene

Also Known as Fast1; Fast2; fast-1; fast-2

Species: Mus musculus

Gene Type: protein coding

Gene ID: 14106

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; R-SMAD binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including aorta morphogenesis; heart morphogenesis; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including axial mesoderm development; determination of left/right symmetry; and embryonic heart tube anterior/posterior pattern specification. Located in nucleus. Part of activin responsive factor complex. Is expressed in several structures, including early conceptus; lung; notochord; ovary; and ureter. Used to study agnathia-otocephaly complex and visceral heterotaxy. Orthologous to human FOXH1 (forkhead box H1). [provided by Alliance of Genome Resources, Apr 2022]

Foxh1 Products (1)

mRNA	Protein	Name
NM_007989.4	NP_032015.1	forkhead box protein H1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9702197	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18331719	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	15363409	MGI
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	9702197	MGI
enables R-SMAD binding	IDA IDA: Inferred from direct assay	9858566	MGI
enables SMAD binding	IPI IPI: Inferred from physical interaction	9702197	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	9702197	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	17568773	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	9858566	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	11358868	MGI
involved in aorta morphogenesis	IMP IMP: Inferred from mutant phenotype	15363409	MGI
acts upstream of or within axial mesoderm development	IMP IMP: Inferred from mutant phenotype	11358869	MGI
involved in cardiac right ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	15363409	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	12642485	MGI
acts upstream of or within embryonic heart tube anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	15363409	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	15363409	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	17568773	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15363409	MGI
involved in outflow tract morphogenesis	IMP IMP: Inferred from mutant phenotype	15363409	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	10349617	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9858566	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15363409	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9702197	MGI
involved in secondary heart field specification	IMP IMP: Inferred from mutant phenotype	15363409	MGI
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	10349617	MGI
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9858566	MGI
involved in ventricular trabecula myocardium morphogenesis	IMP IMP: Inferred from mutant phenotype	15363409	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of activin responsive factor complex	IDA IDA: Inferred from direct assay	9858566	MGI
located in nucleus	IDA IDA: Inferred from direct assay	9702197	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	9702197	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
forkhead box protein H1	FAST1 transcription factor forkhead activin signal transducer 1 forkhead activin signal transducer 2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05052	FOXH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Foxh1	NCBI	NCBI:8928