Fut2 - fucosyltransferase 2 Gene

Also Known as MFUT-II

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14344

Summary

This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with Microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Fut2 Products (2)

mRNA Protein Name
NM_001271993.1 NP_001258922.1 galactoside alpha-(1,2)-fucosyltransferase 2
NM_018876.4 NP_061364.2 galactoside alpha-(1,2)-fucosyltransferase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables alpha-(1,2)-fucosyltransferase activity IDA
IDA: Inferred from direct assay
11018479 MGI
enables alpha-(1,2)-fucosyltransferase activity IMP
IMP: Inferred from mutant phenotype
11713270 MGI
enables fucosyltransferase activity IDA
IDA: Inferred from direct assay
11018479 MGI
enables galactoside 2-alpha-L-fucosyltransferase activity IDA
IDA: Inferred from direct assay
11323419 MGI
enables galactoside 2-alpha-L-fucosyltransferase activity IMP
IMP: Inferred from mutant phenotype
24062455 MGI
Biological Process GO Annotation Evidence References Source
involved in fucosylation IDA
IDA: Inferred from direct assay
11018479 MGI
involved in fucosylation IMP
IMP: Inferred from mutant phenotype
11713270 MGI
involved in glycolipid metabolic process IMP
IMP: Inferred from mutant phenotype
14967068 MGI
involved in oligosaccharide biosynthetic process IDA
IDA: Inferred from direct assay
11323419 MGI
acts upstream of or within protein glycosylation IDA
IDA: Inferred from direct assay
11323419 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

galactoside alpha-(1,2)-fucosyltransferase 2

  • GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2

  • GDP-fucose: beta-galactoside alpha1,2-fucosyltransferase

  • alpha(1,2)FT 2

  • galactoside 2-alpha-L-fucosyltransferase 2

  • secretory blood group protein 2

  • type 1 galactoside alpha-(1,2)-fucosyltr

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05153 FUT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fut2 NCBI NCBI:2524