Gcnt2 - glucosaminyl (N-acetyl) transferase 2, I-branching enzyme Gene

Mus musculus

Also known as IGnT; IGnTA; IGnTB; IGnTC; 5330430K10Rik

Gene ID: 14538 | Gene type: protein coding

About Gcnt2

Summary

Enables acetylglucosaminyltransferase activity. Involved in several processes, including positive regulation of epithelial to mesenchymal transition; positive regulation of intracellular signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; extraembryonic component; nervous system; nose; and trunk mesenchyme. Human ortholog(s) of this gene implicated in cataract and cataract 13 with adult i phenotype. Orthologous to human GCNT2 (glucosaminyl (N-acetyl) transferase 2 (I blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Gcnt2 Products(3)

mRNA	Protein	Name
NM_008105.4	NP_032131.2	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform A
NM_023887.5	NP_076376.3	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform B
NM_133219.2	NP_573482.1	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform C

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetylglucosaminyltransferase activity	IDA IDA: Inferred from direct assay	12670491	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21750175	MGI
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21750175	MGI
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	21750175	MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: Inferred from mutant phenotype	21750175	MGI
involved in post-transcriptional regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21750175	MGI
involved in transforming growth factor beta receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	21750175	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

I-branching enzyme	N-acetylglucosaminyltransferase
beta-1,6-N-acetylglucosaminyltransferase	glucosaminyltransferase, I-branching enzyme
large I antigen-forming beta-1,6-N-acetylglucosaminyltransferase

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-E70143	Glucosaminyl (N-acetyl) Transferase 2		/	Unkown
HY-RS05340	GCNT2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gcnt2	NCBI	NCBI:2651

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