Gcnt2 - glucosaminyl (N-acetyl) transferase 2, I-branching enzyme Gene

Also Known as IGnT; IGnTA; IGnTB; IGnTC; 5330430K10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14538

Summary

Enables acetylglucosaminyltransferase activity. Involved in several processes, including positive regulation of epithelial to mesenchymal transition; positive regulation of intracellular signal transduction; and transforming growth factor beta receptor signaling pathway. Predicted to be located in Golgi apparatus. Is expressed in several structures, including alimentary system; extraembryonic component; nervous system; nose; and trunk mesenchyme. Human ortholog(s) of this gene implicated in cataract and cataract 13 with adult i phenotype. Orthologous to human GCNT2 (glucosaminyl (N-acetyl) transferase 2 (I blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Gcnt2 Products (3)

mRNA Protein Name
NM_008105.4 NP_032131.2 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform A
NM_023887.5 NP_076376.3 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform B
NM_133219.2 NP_573482.1 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase isoform C

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables acetylglucosaminyltransferase activity IDA
IDA: Inferred from direct assay
12670491 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
21750175 MGI
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
21750175 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: Inferred from mutant phenotype
21750175 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
21750175 MGI
involved in post-transcriptional regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21750175 MGI
involved in transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21750175 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase

  • I-branching enzyme

  • N-acetylglucosaminyltransferase

  • beta-1,6-N-acetylglucosaminyltransferase

  • glucosaminyltransferase, I-branching enzyme

  • large I antigen-forming beta-1,6-N-acetylglucosaminyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-E70143 Glucosaminyl (N-acetyl) Transferase 2 / Unkown
HY-RS05340 GCNT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gcnt2 NCBI NCBI:2651