Gna11 - guanine nucleotide binding protein, alpha 11 Gene

Mus musculus

Also known as Dsk7; Hg1k; E430025L19; g alpha-11

Gene ID: 14672 | Gene type: protein coding

About Gna11

Summary

Predicted to enable several functions, including G-protein beta/gamma-subunit complex binding activity; GTPase activity; and alkylglycerophosphoethanolamine phosphodiesterase activity. Involved in several processes, including cranial skeletal system development; Endothelin Receptor signaling pathway; and multicellular organism aging. Acts upstream of or within several processes, including cellular response to pH; Phospholipase C-activating Dopamine Receptor signaling pathway; and regulation of melanocyte differentiation. Predicted to be located in cytosol and plasma membrane. Predicted to be part of heterotrimeric G-protein complex. Is expressed in several structures, including adrenal gland; alimentary system; cardiovascular system; central nervous system; and genitourinary system. Used to study autosomal dominant hypocalcemia 2. Human ortholog(s) of this gene implicated in autosomal dominant hypocalcemia 2 and familial hypocalciuric hypercalcemia 2. Orthologous to human GNA11 (G protein subunit alpha 11). [provided by Alliance of Genome Resources, Apr 2022]

Gna11 Products(1)

mRNA	Protein	Name
NM_010301.4	NP_034431.1	guanine nucleotide-binding protein subunit alpha-11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein activity	IMP IMP: Inferred from mutant phenotype	26075576	MGI
enables enzyme regulator activity	IMP IMP: Inferred from mutant phenotype	26075576	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	26208885	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9687499	MGI
acts upstream of or within action potential	IDA IDA: Inferred from direct assay	10818132	MGI
acts upstream of or within cellular response to pH	IMP IMP: Inferred from mutant phenotype	22733973	MGI
involved in cranial skeletal system development	IGI IGI: Inferred from genetic interaction	18199583	MGI
acts upstream of or within developmental pigmentation	IMP IMP: Inferred from mutant phenotype	15322542	MGI
involved in endothelin receptor signaling pathway	IGI IGI: Inferred from genetic interaction	18199583	MGI
NOT acts upstream of or within glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11438569	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	9687499	MGI
involved in ion channel modulating, G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20440069	MGI
involved in ligand-gated ion channel signaling pathway	IGI IGI: Inferred from genetic interaction	20440069	MGI
involved in ligand-gated ion channel signaling pathway	IMP IMP: Inferred from mutant phenotype	26075576	MGI
involved in phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20440069	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	20440069	MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	26075576	MGI
acts upstream of or within phospholipase C-activating dopamine receptor signaling pathway	IGI IGI: Inferred from genetic interaction	17194762	MGI
involved in positive regulation of insulin secretion	IGI IGI: Inferred from genetic interaction	20440069	MGI
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	26075576	MGI
involved in regulation of blood pressure	IGI IGI: Inferred from genetic interaction	26531127	MGI
acts upstream of or within regulation of melanocyte differentiation	IMP IMP: Inferred from mutant phenotype	15322542	MGI
acts upstream of or within skeletal system development	IMP IMP: Inferred from mutant phenotype	9687499	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	9765251	MGI
is active in plasma membrane	IGI IGI: Inferred from genetic interaction	20440069	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein subunit alpha-11

G-protein subunit alpha-11

heterotrimeric guanine nucleotide-binding protein 1k

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05529	GNA11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gna11	NCBI	NCBI:2767

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