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ZNF582 - zinc finger protein 582 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 147948

About ZNF582

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:56,382,751-56,393,534 (from NCBI)

This gene has 6 transcripts (splice variants), 148 orthologues and 62 paralogues. Ubiquitous expression in thyroid (RPKM 2.0), testis (RPKM 2.0) and 25 other tissues.

Summary

The protein encoded by this gene is a zing finger protein and putative transcription factor that is highly methylated in cervical cancers. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

ZNF582 Products (2)

mRNA	Protein	Name
NM_001320371.4	NP_001307300.2	zinc finger protein 582
NM_144690.3	NP_653291.1	zinc finger protein 582

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF582 Protein Structure

KRAB

zf-H2C2_2

0
100
200
300
400
517 a.a.

Protein Preferred Names	Protein Names
zinc finger protein 582

ZNF582 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZNF582	Q96NG8	NECTIN4	Homo sapiens	Q96NY8	Anti Tag CoIP	33961781
Intra	ZNF582	Q96NG8	NECTIN4	Homo sapiens	Q96NY8	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Anal Squamous Cell Carcinoma	Epidermoid Anal Carcinoma Carcinoma Of Anal Margin
Chronic Cervicitis
Vulva Cancer	Vulvar Carcinoma Malignant Neoplasm Of Vulva Vulva Carcinoma Carcinoma Of Vulva Vulvar Cancer Vulval Cancer Vulvar Neoplasms Ca Vulva Malignant Tumor Of Vulva Malignant Vulvar Tumor Neoplasm Of Vulva Vulval Neoplasm Vulvar Neoplasm Vulvar Tumor Cancer Of Vulva Malignant Tumour Of Vulva
Uterus Carcinoma In Situ
Cervix Uteri Carcinoma In Situ	Carcinoma In Situ Of Cervix Carcinoma In Situ Of Uterine Cervix Cervical Intraepithelial Neoplasia Carcinoma Of Cervix Stage 0 Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia Cervix Ca In Situ Cin Iii Cin Iii - Carcinoma In Situ Of Cervix Cin Iii - Severe Dyskaryosis Severe Dysplasia Of Cervix Severe Dysplasia Of The Cervix Uteri Squamous Intraepithelial Neoplasia, Grade Iii Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7
Vulva Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Vulva Vulvar Squamous Cell Carcinoma Vulvar Epidermoid Carcinoma Squamous Cell Carcinoma Of The Vulva
Anus Cancer	Anal Cancer Anal Carcinoma Malignant Anal Tumor Cancer Of The Anus Malignant Neoplasm Of Anus Anus Neoplasms
Cervicitis	Uterine Cervicitis Inflammation Of Cervix
Anus Disease	Anal Fissure Ulcer Of Anus Anus Diseases Anal Disease Anal Fissure And Fistula Anal Ulcer Fissure In Ano Nontraumatic Tear Of Anus Solitary Anal Ulcer Abnormality Of The Anus Anal Disorders Ulcer Of Anus And Rectum Solitary Ulcer Of Anus Stercoral Ulcer Of Anus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16154	ZNF582 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF582	RGD	RGD:7617005
Mus musculus	ZNF582	MGD	MGI:3782026
Macaca mulatta	ZNF582	VGNC	VGNC:79608
Canis familiaris	ZNF582	VGNC	VGNC:48766