Hyal2 - hyaluronoglucosaminidase 2 Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15587

Summary

Enables enzyme binding activity; transforming growth factor beta binding activity; and virus receptor activity. Contributes to transcription coactivator activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; defense response to virus; and positive regulation of protein import into nucleus. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; multicellular organismal iron ion homeostasis; and positive regulation of extrinsic apoptotic signaling pathway. Located in cell surface and membrane raft. Is anchored component of plasma membrane. Part of RNA polymerase II transcription regulator complex. Colocalizes with anchored component of external side of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; heart; lateral plate mesoderm; and respiratory system. Orthologous to human HYAL2 (hyaluronidase 2). [provided by Alliance of Genome Resources, Apr 2022]

Hyal2 Products (3)

mRNA	Protein	Name
NM_001409671.1	NP_001396600.1	hyaluronidase-2 precursor
NM_001409672.1	NP_001396601.1	hyaluronidase-2 precursor
NM_010489.3	NP_034619.2	hyaluronidase-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	19366691	MGI
enables hyalurononglucosaminidase activity	IMP IMP: Inferred from mutant phenotype	26887442	MGI
contributes to transcription coactivator activity	IDA IDA: Inferred from direct assay	19366691	MGI
enables transforming growth factor beta binding	IPI IPI: Inferred from physical interaction	19366691	MGI
NOT enables virus receptor activity	IDA IDA: Inferred from direct assay	16191204	MGI
enables virus receptor activity	IDA IDA: Inferred from direct assay	11296287	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to transforming growth factor beta stimulus	IDA IDA: Inferred from direct assay	19366691	MGI
involved in defense response to virus	IDA IDA: Inferred from direct assay	16191204	MGI
acts upstream of or within hematopoietic progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	18772348	MGI
involved in hyaluronan catabolic process	IMP IMP: Inferred from mutant phenotype	23172227	MGI
acts upstream of or within multicellular organismal-level iron ion homeostasis	IMP IMP: Inferred from mutant phenotype	18772348	MGI
acts upstream of or within positive regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	19366691	MGI
involved in positive regulation of extrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	19366691	MGI
involved in positive regulation of protein import into nucleus	IDA IDA: Inferred from direct assay	19366691	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19366691	MGI
involved in response to virus	IDA IDA: Inferred from direct assay	11296287	MGI
acts upstream of or within skeletal system morphogenesis	IMP IMP: Inferred from mutant phenotype	18772348	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	19366691	MGI
located in cell surface	IDA IDA: Inferred from direct assay	19366691	MGI
NOT located in external side of plasma membrane	IDA IDA: Inferred from direct assay	16191204	MGI
colocalizes with external side of plasma membrane	IDA IDA: Inferred from direct assay	19443707	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	21740893	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	21740893	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hyaluronidase-2	hyal-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2096	Hexapeptide-11		99.77%	Unkown
HY-E70182	Hyaluronidase 2	Inhibitor	/	Unkown
HY-RS06496	HYAL2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hyal2	NCBI	NCBI:8692