Kcne1 - potassium voltage-gated channel, Isk-related subfamily, member 1 Gene

Mus musculus

Also known as Isk; MinK; nmf190

Gene ID: 16509 | Gene type: protein coding

About Kcne1

Summary

Enables Potassium Channel regulator activity. Involved in potassium ion transmembrane transport; secretory granule organization; and vestibular nucleus development. Acts upstream of or within epithelial cell maturation; heart contraction; and regulation of heart rate by cardiac conduction. Located in apical plasma membrane. Is active in cell surface. Is expressed in several structures, including ear; embryo ectoderm; genitourinary system; great vessel of heart; and heart. Used to study Jervell-Lange Nielsen syndrome. Human ortholog(s) of this gene implicated in Jervell-Lange Nielsen syndrome; atrial fibrillation; long QT syndrome; and long QT syndrome 5. Orthologous to human KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcne1 Products(2)

mRNA	Protein	Name
NM_001362456.1	NP_001349385.1	potassium voltage-gated channel subfamily E member 1
NM_008424.3	NP_032450.1	potassium voltage-gated channel subfamily E member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables potassium channel regulator activity	IDA IDA: Inferred from direct assay	8900282	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19623261	MGI
NOT enables voltage-gated potassium channel activity	IDA IDA: Inferred from direct assay	8900282	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within epithelial cell maturation	IMP IMP: Inferred from mutant phenotype	11223304	MGI
acts upstream of or within heart contraction	IMP IMP: Inferred from mutant phenotype	14561835	MGI
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	11889581	MGI
acts upstream of or within regulation of heart rate by cardiac conduction	IMP IMP: Inferred from mutant phenotype	14561835	MGI
involved in secretory granule organization	IMP IMP: Inferred from mutant phenotype	11889581	MGI
involved in vestibular nucleus development	IMP IMP: Inferred from mutant phenotype	11223304	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in apical plasma membrane	IDA IDA: Inferred from direct assay	11223304	MGI
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11223304	MGI
part of voltage-gated potassium channel complex	IPI IPI: Inferred from physical interaction	8900282	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

potassium voltage-gated channel subfamily E member 1

IKs producing slow voltage-gated potassium channel subunit beta Mink	delayed rectifier potassium channel subunit IsK
minimal potassium channel

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120960	N-Arachidonoyl-L-serine		/	Unkown
HY-122504	Linoleoyl glycine	Inhibitor	/	Unkown
HY-RS07115	KCNE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kcne1	NCBI	NCBI:3753

Name
Email *

	Sorry, but the email address you supplied was invalid.