Kcne1 - potassium voltage-gated channel, Isk-related subfamily, member 1 Gene

Also Known as Isk; MinK; nmf190

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16509

Summary

Enables Potassium Channel regulator activity. Involved in potassium ion transmembrane transport; secretory granule organization; and vestibular nucleus development. Acts upstream of or within epithelial cell maturation; heart contraction; and regulation of heart rate by cardiac conduction. Located in apical plasma membrane. Is active in cell surface. Is expressed in several structures, including ear; embryo ectoderm; genitourinary system; great vessel of heart; and heart. Used to study Jervell-Lange Nielsen syndrome. Human ortholog(s) of this gene implicated in Jervell-Lange Nielsen syndrome; atrial fibrillation; long QT syndrome; and long QT syndrome 5. Orthologous to human KCNE1 (potassium voltage-gated channel subfamily E regulatory subunit 1). [provided by Alliance of Genome Resources, Apr 2022]

Kcne1 Products (2)

mRNA Protein Name
NM_001362456.1 NP_001349385.1 potassium voltage-gated channel subfamily E member 1
NM_008424.3 NP_032450.1 potassium voltage-gated channel subfamily E member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables potassium channel regulator activity IDA
IDA: Inferred from direct assay
8900282 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
19623261 MGI
NOT enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
8900282 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within epithelial cell maturation IMP
IMP: Inferred from mutant phenotype
11223304 MGI
acts upstream of or within heart contraction IMP
IMP: Inferred from mutant phenotype
14561835 MGI
involved in potassium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
11889581 MGI
acts upstream of or within regulation of heart rate by cardiac conduction IMP
IMP: Inferred from mutant phenotype
14561835 MGI
involved in secretory granule organization IMP
IMP: Inferred from mutant phenotype
11889581 MGI
involved in vestibular nucleus development IMP
IMP: Inferred from mutant phenotype
11223304 MGI
Cellular Component GO Annotation Evidence References Source
is active in apical plasma membrane IDA
IDA: Inferred from direct assay
11223304 MGI
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11223304 MGI
part of voltage-gated potassium channel complex IPI
IPI: Inferred from physical interaction
8900282 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily E member 1

  • IKs producing slow voltage-gated potassium channel subunit beta Mink

  • delayed rectifier potassium channel subunit IsK

  • minimal potassium channel

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120960 N-Arachidonoyl-L-serine 98% Unkown
HY-122504 Linoleoyl glycine Inhibitor / Unkown
HY-184207 Zinc13732787 Inhibitor / Unkown
HY-RS07115 KCNE1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcne1 NCBI NCBI:3753