2. Gene
  3. Krt10 - keratin 10 Gene

Krt10 - keratin 10 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as K10; K1C1; Krt1-10; Krt-1.10; D130054E02Rik

Gene ID: 16661 | Gene type: protein coding

About Krt10

Summary

Enables cytoskeletal protein binding activity. Involved in positive regulation of epidermis development. Acts upstream of or within cellular response to calcium ion; intermediate filament organization; and keratinocyte development. Located in keratin filament. Is expressed in several structures, including alimentary system; lower urinary tract; respiratory system; sensory organ; and skin. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis. Orthologous to human KRT10 (keratin 10). [provided by Alliance of Genome Resources, Apr 2022]

Krt10 Products(1)

mRNA Protein Name
NM_010660.2 NP_034790.2 keratin, type I cytoskeletal 10
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cytoskeletal protein binding IGI
IGI: Inferred from genetic interaction
24751727 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
19303854 MGI
acts upstream of or within epidermis development IGI
IGI: Inferred from genetic interaction
24751727 MGI
acts upstream of or within intermediate filament organization IGI
IGI: Inferred from genetic interaction
24751727 MGI
acts upstream of or within keratinocyte development IGI
IGI: Inferred from genetic interaction
24751727 MGI
acts upstream of or within keratinocyte differentiation IDA
IDA: Inferred from direct assay
19303854 MGI
involved in positive regulation of epidermis development IMP
IMP: Inferred from mutant phenotype
26603179 MGI
acts upstream of or within stem cell differentiation IDA
IDA: Inferred from direct assay
19303854 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24751727 MGI
located in keratin filament IDA
IDA: Inferred from direct assay
7679677 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type I cytoskeletal 10

56 kDa cytokeratin

CK-10

cytokeratin-10

epidermal keratin 10

intermediate filament protein

keratin complex 1, acidic, gene 10

keratin, type I cytoskeletal 59 kDa

suprabasal cytokeratin 10

Krt10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Krt10 P02535 Chuk Mus musculus Q60680-1
Y2H
15102471
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07434 KRT10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt10 NCBI NCBI:3858