Krt10 - keratin 10 Gene

Also Known as K10; K1C1; Krt1-10; Krt-1.10; D130054E02Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16661

Summary

Enables cytoskeletal protein binding activity. Involved in positive regulation of epidermis development. Acts upstream of or within cellular response to calcium ion; intermediate filament organization; and keratinocyte development. Located in keratin filament. Is expressed in several structures, including alimentary system; lower urinary tract; respiratory system; sensory organ; and skin. Used to study epidermolytic hyperkeratosis. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis. Orthologous to human KRT10 (keratin 10). [provided by Alliance of Genome Resources, Apr 2022]

Krt10 Products (1)

mRNA Protein Name
NM_010660.2 NP_034790.2 keratin, type I cytoskeletal 10

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cytoskeletal protein binding IGI
IGI: Inferred from genetic interaction
24751727 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15102471 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
19303854 MGI
acts upstream of or within epidermis development IGI
IGI: Inferred from genetic interaction
24751727 MGI
acts upstream of or within intermediate filament organization IGI
IGI: Inferred from genetic interaction
24751727 MGI
acts upstream of or within keratinocyte development IGI
IGI: Inferred from genetic interaction
24751727 MGI
acts upstream of or within keratinocyte differentiation IDA
IDA: Inferred from direct assay
19303854 MGI
involved in positive regulation of epidermis development IMP
IMP: Inferred from mutant phenotype
26603179 MGI
acts upstream of or within stem cell differentiation IDA
IDA: Inferred from direct assay
19303854 MGI
Cellular Component GO Annotation Evidence References Source
is active in cornified envelope IDA
IDA: Inferred from direct assay
26644517 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
24751727 MGI
located in keratin filament IDA
IDA: Inferred from direct assay
7679677 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

keratin, type I cytoskeletal 10

  • 56 kDa cytokeratin

  • CK-10

  • cytokeratin-10

  • epidermal keratin 10

  • intermediate filament protein

  • keratin complex 1, acidic, gene 10

  • keratin, type I cytoskeletal 59 kDa

  • suprabasal cytokeratin 10

Krt10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Krt10 P02535 Chuk Mus musculus Q60680-1
Y2H
15102471
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07434 KRT10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Krt10 NCBI NCBI:3858