Hadha - hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha Gene

Also Known as RGD1560655

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 170670

Summary

Enables several functions, including hydro-lyase activity; long-chain-3-hydroxyacyl-CoA dehydrogenase activity; and nucleotide binding activity. Involved in fatty acid beta-oxidation and response to xenobiotic stimulus. Located in mitochondrion. Part of mitochondrial fatty acid beta-oxidation multienzyme complex. Biomarker of non-alcoholic fatty liver disease. Human ortholog(s) of this gene implicated in fatty liver disease and mitochondrial trifunctional protein deficiency. Orthologous to human HADHA (hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Hadha Products (1)

mRNA Protein Name
NM_130826.2 NP_570839.2 trifunctional enzyme subunit alpha, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-hydroxyacyl-CoA dehydratase activity IDA
IDA: Inferred from direct assay
1730633 RGD
enables 3-hydroxyacyl-CoA dehydrogenase activity IDA
IDA: Inferred from direct assay
1730633 RGD
enables 3-hydroxyacyl-CoA dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
8253773 RGD
enables NAD binding IDA
IDA: Inferred from direct assay
1730633 RGD
enables acetyl-CoA C-acyltransferase activity IDA
IDA: Inferred from direct assay
1730633 RGD
enables enoyl-CoA hydratase activity IDA
IDA: Inferred from direct assay
1730633 RGD
enables enoyl-CoA hydratase activity IMP
IMP: Inferred from mutant phenotype
8253773 RGD
enables fatty-acyl-CoA binding IDA
IDA: Inferred from direct assay
1730633 RGD
enables long-chain-3-hydroxyacyl-CoA dehydrogenase activity IDA
IDA: Inferred from direct assay
1730633 RGD
enables protein-containing complex binding IMP
IMP: Inferred from mutant phenotype
20132223 RGD
Biological Process GO Annotation Evidence References Source
involved in fatty acid beta-oxidation IDA
IDA: Inferred from direct assay
1730633 RGD
involved in response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
12176671 RGD
Cellular Component GO Annotation Evidence References Source
part of mitochondrial fatty acid beta-oxidation multienzyme complex IDA
IDA: Inferred from direct assay
1730633 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

trifunctional enzyme subunit alpha, mitochondrial

  • TP-alpha

  • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

  • hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subun

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0968A Trimetazidine Inducer 99.84% Yes
HY-B0968 Trimetazidine dihydrochloride Inducer 99.94% Yes
HY-B0968R Trimetazidine dihydrochloride (Standard) Inducer 99.94% Unkown

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-B0968S Trimetazidine-d8 dihydrochloride Inducer 99.87% Unkown
HY-RS05990 HADHA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0968S1 Trimetazidine-d9 dihydrochloride Inducer / Unkown
HY-RS17506 Hadha Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23963 Hadha Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hadha NCBI NCBI:3030